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Thorac Cardiovasc Surg 2013; 61(05): 435-437
DOI: 10.1055/s-0032-1331580
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Cardiac Surgery for Ergotamine-Induced Multivalvular Heart Disease

George Lazopoulos
1   Department of Cardiac Surgery, Athens Medical Center, Athens, Greece
,
George Papaioannou
2   Department of Cardiology, Athens Medical Center, Athens, Greece
,
Michael Kantartzis
1   Department of Cardiac Surgery, Athens Medical Center, Athens, Greece
› Institutsangaben
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Publikationsverlauf

14. September 2012

28. September 2012

Publikationsdatum:
08. März 2013 (online)

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Abstract

Ergotamine is used to abort or prevent vascular headache. Valvular heart disease as an adverse effect of long-term ergotamine therapy has been rarely reported in the English literature, with only a few cases published. It is hypothesized that ergot-derived agents stimulate serotonergic receptors (5-HT2B), causing proliferation of myofibroblasts, with subsequent thickening of valve leaflets and chords. This case presentation aims at increasing clinicians' awareness of this potential complication.

Keywords

ergotamine - cardiac valve - cardiac surgery
 

  • References

  • 1 Sutton RAL. Arteriospasm after ergotamine tartrate. BMJ 1964; 2 (5411) 756-757
    PubMedSuche in Google Scholar
  • 2 Austin SM, el-Hayek A, Comianos M, Tamulonis DJ. Mitral valve disease associated with long-term ergotamine use. South Med J 1993; 86 (10) 1179-1181
    CrossrefPubMedSuche in Google Scholar
  • 3 Rothman RB, Baumann MH, Savage JE , et al. Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation 2000; 102 (23) 2836-2841
    CrossrefPubMedSuche in Google Scholar
  • 4 Rasmussen VG, Poulsen SH, Dupont E, Ostergaard K, Safikhany G, Egeblad H. Ergotamine-derived dopamine agonists and left ventricular function in Parkinson patients: systolic and diastolic function studied by conventional echocardiography, tissue Doppler imaging, and two-dimensional speckle tracking. Eur J Echocardiogr 2008; 9 (6) 803-808
    CrossrefPubMedSuche in Google Scholar
  • 5 Elangbam CS, Colman KA, Lightfoot RM, Tyler RD, Wall HG. Endocardial myxomatous change in Harlan Sprague-Dawley rats (Hsd:S-D) and CD-1 mice: its microscopic resemblance to drug-induced valvulopathy in humans. Toxicol Pathol 2002; 30 (4) 483-491
    CrossrefPubMedSuche in Google Scholar
  • 6 Connolly HM, Crary JL, McGoon MD , et al. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 1997; 337 (9) 581-588
    CrossrefPubMedSuche in Google Scholar
  • 7 Antonini A, Poewe W. Fibrotic heart-valve reactions to dopamine-agonist treatment in Parkinson's disease. Lancet Neurol 2007; 6 (9) 826-829
    CrossrefPubMedSuche in Google Scholar
  • 8 Bhattacharyya S, Schapira AH, Mikhailidis DP, Davar J. Drug-induced fibrotic valvular heart disease. Lancet 2009; 374 (9689) 577-585
    CrossrefPubMedSuche in Google Scholar