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Exp Clin Endocrinol Diabetes 2013; 121(02): 115-118
DOI: 10.1055/s-0032-1333261
Article
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Lipid Accumulation Product is Related to Metabolic Syndrome in Women with Polycystic Ovary Syndrome

S. Xiang
1   Department of Endocrinology. the Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
,
F. Hua
1   Department of Endocrinology. the Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
,
L. Chen
1   Department of Endocrinology. the Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
,
Y. Tang
1   Department of Endocrinology. the Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
,
X. Jiang
1   Department of Endocrinology. the Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
,
Z. Liu
1   Department of Endocrinology. the Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
› Author Affiliations
Further Information

Publication History

received 19 July 2012
first decision 19 July 2012

accepted 21 December 2012

Publication Date:
20 February 2013 (online)

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Abstract

Purpose:

Metabolic disturbances are common features of polycystic ovary syndrome (PCOS), which possibly enhance the risk of diabetes and cardiovascular disease. Lipid accumulation product (LAP) is an emerging cardiovascular risk factor. The aim of this study was to explore the ability of LAP to identify metabolic syndrome (MS) in PCOS women.

Methods:

In a cross-sectional study, anthropometric, biochemical and clinical parameters were measured in 105 PCOS women. Receiver operating characteristic (ROC) analysis was used to find out the cut-off points of LAP to predict MS. MS was categorized according to International Diabetes Federation (IDF) criteria.

Results:

The prevalence of MS was 43.8% in this study. PCOS women with MS had significantly higher LAP levels compared to those without MS. LAP was highly correlated with components of MS. ROC analysis showed that LAP was a significant discriminator for MS in PCOS women, and the optimal cutoff point of LAP to predict MS was 54.2 (93.3% sensitivity, 96.7% specificity).

Conclusions:

LAP seems to be associated with MS and has a strong and reliable diagnostic accuracy for MS in PCOS women.

Key words

polycystic ovary syndrome - metabolic syndrome - lipid accumulation product
 

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