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Semin Reprod Med 2013; 31(02): 109-124
DOI: 10.1055/s-0032-1333476
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Eutopic Endometrium in Women with Endometriosis: Ground Zero for the Study of Implantation Defects

Bruce A. Lessey
1   Greenville Hospital System, University of South Carolina School of Medicine, Greenville, Greenville, South Carolina
,
Dan I. Lebovic
2   University of Wisconsin School of Medicine, Middleton, Wisconsin
,
Robert N. Taylor
3   Wake Forest University School of Medicine, Winston-Salem, North Carolina
› Author Affiliations
Further Information

Publication History

Publication Date:
27 February 2013 (online)

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Abstract

The endometrium is ground zero when it comes to understanding how implantation occurs and how it might also fail, resulting in infertility or pregnancy loss. Many of the causes of diminished uterine receptivity are acquired during a woman's lifetime. Endometriosis, a major inflammatory disease affecting women, is also a leading cause of infertility and miscarriage. Once established, the inflammatory changes can, in some women, lead to progesterone resistance and downstream changes in endometrial gene expression. Much is now known about how inflammation translates to progesterone resistance and infertility, but much remains to be learned. In this review we provide an overview for understanding how the endometrium becomes dysfunctional, what biomarkers may hold promise for the diagnosis of endometriosis, and how progesterone resistance leads to infertility. Understanding the pathophysiology of this disease will likely lead to better treatment options.

Keywords

adhesion - endometriosis - inflammation - implantation - progesterone - biomarkers
 

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