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Synthesis 2013; 45(11): 1513-1518
DOI: 10.1055/s-0033-1338432
DOI: 10.1055/s-0033-1338432
paper
A Practical Total Synthesis of Both E- and Z-Isomers of Optically Pure (S)-14-Methylhexadec-8-enal (Trogodermal)
Weitere Informationen
Publikationsverlauf
Received: 22. Januar 2013
Accepted after revision: 28. März 2013
Publikationsdatum:
08. Mai 2013 (online)
Abstract
The total synthesis of both E- and Z-isomers of optically pure (S)-14-methylhexadec-8-enal (trogodermal) is described. Key steps involved Corey–Fuchs reaction, zipper isomerization, and different hydrogenation conditions for cis- and trans-isomers.
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