Highly Enantioselective Michael Addition of α-Substituted Nitrophosphonates to a Vinyl Sulfone

Guo-Ying Chen; Yixin Lu

doi:10.1055/s-0033-1338434

Synthesis, Inhaltsverzeichnis

Synthesis 2013; 45(12): 1654-1658
DOI: 10.1055/s-0033-1338434

special topic

Highly Enantioselective Michael Addition of α-Substituted Nitrophosphonates to a Vinyl Sulfone

Guo-Ying Chen

Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore Fax: +65(6779)1691 eMail: chmlyx@nus.edu.sg

,

Yixin Lu*

Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore Fax: +65(6779)1691 eMail: chmlyx@nus.edu.sg

› Institutsangaben

Abstract

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Abstract

Organocatalytic asymmetric Michael reaction of α-substituted nitrophosphonates to phenyl vinyl sulfone catalyzed by cinchona alkaloid-derived tertiary amine-thioureas afforded α,α-disubstituted nitrophosphonates in very good yields and excellent enantiomeric excesses.

Key words

thiourea - Michael Addition - cinchona alkaloid - vinyl sulfone - nitrophosphonate

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Referenzen

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