Efficient Synthesis of 2-Ureaguanines via the in situ Reactions of 2-Isocyanatopurines with Amines

Abstract

The synthesis of 2-ureaguanines is reported. The preparation involves a suitably protected intermediate, formation of a 2-isocyanatopurine and in situ trapping with a diverse range of amines followed by double deprotection. This is the first application of 2-isocyanatopurines for the synthesis of 2-ureaguanines.

Key words

guanine - purines - heterocycles - isocyanates - ureas - triphosgene

• References

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