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Synthesis 2013; 45(14): 1909-1930
DOI: 10.1055/s-0033-1338484
DOI: 10.1055/s-0033-1338484
review
Enantioselective Organocatalyzed Domino Synthesis of Six-Membered Carbocycles
Further Information
Publication History
Received: 18 February 2013
Accepted after revision: 08 April 2013
Publication Date:
06 June 2013 (online)
Dedicated to the elegant and stimulating realizations of Professor D. Enders in the field of this review
Abstract
Polysubstituted chiral cyclohexanes and cyclohexenes are important building blocks in organic synthesis. From historical and pioneering reports to the most recent accounts, this review focuses on domino enantioselective organocatalytic methodologies that have allowed the control of the relative and absolute configurations of up to six stereogenic centers in the construction of these versatile molecular architectures.
1 Introduction
2 Two-Component Transformations
2.1 Michael-Initiated Domino Reactions with α,β-Unsaturated Carbonyl Compounds
2.2 Michael-Initiated Domino Reactions with Nitroolefins
2.3 Non Michael-Initiated Domino Reactions
3 Multicomponent and Related Transformations
3.1 Pseudo-Three-Component Reactions
3.1.1 Michael-Initiated Domino Reactions with Nitroolefins
3.1.2 Michael-Initiated Domino Reactions with α,β-Unsaturated Carbonyl Compounds
3.2 Consecutive Reactions
3.2.1 Michael-Initiated Domino Reactions with Nitroolefins
3.2.2 Michael-Initiated Domino Reactions with α,β-Unsaturated Carbonyl Compounds
3.3 Multicomponent Reactions
3.3.1 Michael-Initiated Domino Reactions with Nitroolefins
3.3.2 Michael-Initiated Domino Reactions with α,β-Unsaturated Carbonyl Compounds
4 Conclusion
-
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