Synthesis 2013; 45(18): 2593-2599
DOI: 10.1055/s-0033-1338506
paper
© Georg Thieme Verlag Stuttgart · New York

Efficient One-Pot Synthesis of Spirooxindole Derivatives Bearing Hexahydroquinolines Using Multicomponent Reactions Catalyzed by Ethylenediamine Diacetate

So Rang Kang
School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea   Fax: +82(53)8104631   Email: yrlee@yu.ac.kr
,
Yong Rok Lee*
School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea   Fax: +82(53)8104631   Email: yrlee@yu.ac.kr
› Author Affiliations
Further Information

Publication History

Received: 18 May 2013

Accepted after revision: 24 June 2013

Publication Date:
19 July 2013 (online)


Abstract

A simple and efficient one-pot synthesis of biologically interesting spirooxindole derivatives bearing hexahydroquinoline skeleton was accomplished by EDDA-catalyzed, three-component reactions between isatins, malononitrile, and enaminones in good yields. The value of this methodology lies in its inexpensive and nontoxic organocatalyst, mild reaction conditions, and ease of handling.

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