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Synthesis 2013; 45(18): 2593-2599
DOI: 10.1055/s-0033-1338506
DOI: 10.1055/s-0033-1338506
paper
Efficient One-Pot Synthesis of Spirooxindole Derivatives Bearing Hexahydroquinolines Using Multicomponent Reactions Catalyzed by Ethylenediamine Diacetate
Further Information
Publication History
Received: 18 May 2013
Accepted after revision: 24 June 2013
Publication Date:
19 July 2013 (online)


Abstract
A simple and efficient one-pot synthesis of biologically interesting spirooxindole derivatives bearing hexahydroquinoline skeleton was accomplished by EDDA-catalyzed, three-component reactions between isatins, malononitrile, and enaminones in good yields. The value of this methodology lies in its inexpensive and nontoxic organocatalyst, mild reaction conditions, and ease of handling.
Key words
multicomponent reaction - spirooxindoles - enaminone - hexahydroquinolines - ethylenediamine diacetateSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information