Efficient One-Pot Synthesis of Spirooxindole Derivatives Bearing Hexahydroquinolines Using Multicomponent Reactions Catalyzed by Ethylenediamine Diacetate

So Rang Kang; Yong Rok Lee

doi:10.1055/s-0033-1338506

Synthesis, Inhaltsverzeichnis

Synthesis 2013; 45(18): 2593-2599
DOI: 10.1055/s-0033-1338506

paper

Efficient One-Pot Synthesis of Spirooxindole Derivatives Bearing Hexahydroquinolines Using Multicomponent Reactions Catalyzed by Ethylenediamine Diacetate

So Rang Kang

School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea Fax: +82(53)8104631 eMail: yrlee@yu.ac.kr

,

Yong Rok Lee*

School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea Fax: +82(53)8104631 eMail: yrlee@yu.ac.kr

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Abstract

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Abstract

A simple and efficient one-pot synthesis of biologically interesting spirooxindole derivatives bearing hexahydroquinoline skeleton was accomplished by EDDA-catalyzed, three-component reactions between isatins, malononitrile, and enaminones in good yields. The value of this methodology lies in its inexpensive and nontoxic organocatalyst, mild reaction conditions, and ease of handling.

Key words

multicomponent reaction - spirooxindoles - enaminone - hexahydroquinolines - ethylenediamine diacetate

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References

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