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Synthesis 2013; 45(18): 2533-2544
DOI: 10.1055/s-0033-1338511
DOI: 10.1055/s-0033-1338511
paper
Synthesis of Aroylguanidines by an Unexpected Demethylation–Addition Cascade
Weitere Informationen
Publikationsverlauf
Received: 06. Mai 2013
Accepted after revision: 30. Juni 2013
Publikationsdatum:
01. August 2013 (online)
![](https://www.thieme-connect.de/media/synthesis/201318/lookinside/thumbnails/10.1055-s-0033-1338511-1.jpg)
Abstract
A simple and efficient method was developed for the synthesis of N-aroyl-N′-arylguanidines under mild conditions by an unexpected demethylation–addition cascade reaction of readily available N-cyanoimidates with aryl amines. Moreover, 1-aryl-2-aminoquinazolin-4(1H)-ones and 2-(arylamino)quinazolin-4(3H)-ones can also be prepared by selective cyclization reactions of (2-fluorobenzoyl)- or (2-nitrobenzoyl)guanidines, respectively. This method provided two attractive strategies for the preparation 2-aminoquinazolinones derivatives from inexpensive reactants.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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