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Synthesis 2013; 45(21): 3029-3037
DOI: 10.1055/s-0033-1338524
DOI: 10.1055/s-0033-1338524
paper
Regioselective Functionalization of Purine Derivatives at Positions 8 and 6 Using Hindered TMP-Amide Bases of Zn and Mg
Weitere Informationen
Publikationsverlauf
Received: 05. August 2013
Accepted: 09. August 2013
Publikationsdatum:
02. September 2013 (online)

Abstract
A broad range of purine derivatives were efficiently metalated at positions 8 and 6 using TMP-amide bases. This provided polysubstituted purines in good to very good yields after subsequent trapping of the zinc or magnesium intermediates with various electrophiles.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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