Synthesis 2013; 45(21): 3029-3037
DOI: 10.1055/s-0033-1338524
paper
© Georg Thieme Verlag Stuttgart · New York

Regioselective Functionalization of Purine Derivatives at Positions 8 and 6 Using Hindered TMP-Amide Bases of Zn and Mg

François Crestey
,
Silvia Zimdars
,
Paul Knochel*
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Publikationsverlauf

Received: 05. August 2013

Accepted: 09. August 2013

Publikationsdatum:
02. September 2013 (online)


Abstract

A broad range of purine derivatives were efficiently metalated at positions 8 and 6 using TMP-amide bases. This provided polysubstituted purines in good to very good yields after subsequent trapping of the zinc or magnesium intermediates with various electrophiles.

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