An Efficient and Mild Synthesis of Tetrahydro-4H-indol-4-one Derivatives via a Domino Reaction in Water

Furen Zhang; Chunmei Li; Chenze Qi

doi:10.1055/s-0033-1338526

Synthesis, Inhaltsverzeichnis

Synthesis 2013; 45(21): 3007-3017
DOI: 10.1055/s-0033-1338526

paper

An Efficient and Mild Synthesis of Tetrahydro-4H-indol-4-one Derivatives via a Domino Reaction in Water

Furen Zhang

School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province 312000, P. R. of China Fax: +86(575)88345862 eMail: qichenze@usx.edu.cn

,

Chunmei Li

School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province 312000, P. R. of China Fax: +86(575)88345862 eMail: qichenze@usx.edu.cn

,

Chenze Qi*

School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang Province 312000, P. R. of China Fax: +86(575)88345862 eMail: qichenze@usx.edu.cn

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Abstract

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Abstract

An efficient domino approach for the synthesis of tetrahydro-4H-indol-4-one derivatives has been established. The use of catalytic amount of l-proline in water at 60 °C makes it quite simple, more convenient, and environmentally benign.

Key words

tetrahydro-4H-indol-4-one - amines - cyclization - domino reaction - catalysis

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