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Synthesis 2013; 45(21): 2966-2970
DOI: 10.1055/s-0033-1338528
DOI: 10.1055/s-0033-1338528
paper
Preparation of Novel Bridged Bicyclic Thiomorpholines as Potentially Useful Building Blocks in Medicinal Chemistry
Weitere Informationen
Publikationsverlauf
Received: 24. Juni 2013
Accepted after revision: 19. August 2013
Publikationsdatum:
12. September 2013 (online)
![](https://www.thieme-connect.de/media/synthesis/201321/lookinside/thumbnails/10.1055-s-0033-1338528-1.jpg)
Abstract
Thiomorpholine and thiomorpholine 1,1-dioxide are important building blocks in medicinal chemistry research, and some analogues containing these moieties have entered human clinical trials. Analogues containing bridged bicyclic thiomorpholines have also shown interesting biological profiles. 3-Thia-6-azabicyclo[3.1.1]heptane, 3-thia-8-azabicyclo[3.2.1]octane, and their corresponding 1,1-dioxide counterparts were prepared as novel bicyclic thiomorpholine building blocks. Each heterocycle was synthesized from an inexpensive starting material by straightforward chemistry.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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