Synthesis 2014; 46(02): 203-211
DOI: 10.1055/s-0033-1338557
paper
© Georg Thieme Verlag Stuttgart · New York

Base-Mediated Synthesis of 1-Aryl-4-(phenylsulfonyl)butan-1-ones from 1,2-Bis(phenylsulfonyl)ethane and Ketones

Ye-Xiang Xie
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. of China   Fax: +86(731)88713642   eMail: jhli@hnu.edu.cn   eMail: srj0731@hnu.edu.cn   eMail: jnxiang@hnu.edu.cn
,
Ren-Jie Song*
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. of China   Fax: +86(731)88713642   eMail: jhli@hnu.edu.cn   eMail: srj0731@hnu.edu.cn   eMail: jnxiang@hnu.edu.cn
,
Yu Liu
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. of China   Fax: +86(731)88713642   eMail: jhli@hnu.edu.cn   eMail: srj0731@hnu.edu.cn   eMail: jnxiang@hnu.edu.cn
,
Zhi-Qiang Wang
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. of China   Fax: +86(731)88713642   eMail: jhli@hnu.edu.cn   eMail: srj0731@hnu.edu.cn   eMail: jnxiang@hnu.edu.cn
,
Jian-Nan Xiang*
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. of China   Fax: +86(731)88713642   eMail: jhli@hnu.edu.cn   eMail: srj0731@hnu.edu.cn   eMail: jnxiang@hnu.edu.cn
,
Jin-Heng Li*
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. of China   Fax: +86(731)88713642   eMail: jhli@hnu.edu.cn   eMail: srj0731@hnu.edu.cn   eMail: jnxiang@hnu.edu.cn
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Publikationsverlauf

Received: 20. August 2013

Accepted after revision: 23. Oktober 2013

Publikationsdatum:
14. November 2013 (online)


Abstract

A new, simple, base-mediated addition reaction of 1,2-bis(phenylsulfonyl)ethane to ketones has been developed for the synthesis of 1-aryl-4-(phenylsulfonyl)butan-1-ones. This method represents the first example of preparing sulfones using 1,2-bis(phenylsulfonyl)ethane as the sulfone resource.

Supporting Information