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Synthesis 2014; 46(02): 195-202
DOI: 10.1055/s-0033-1338563
DOI: 10.1055/s-0033-1338563
paper
Catalytic C–H Activation of Arylacetylenes: A Fast Assembly of 3-(Arylethynyl)-3-hydroxyindolin-2-ones Using CuI/DBU
Further Information
Publication History
Received: 27 August 2013
Accepted after revision: 29 October 2013
Publication Date:
28 November 2013 (online)
Abstract
A highly efficient and atom-economic methodology has been developed for the synthesis of 3-(arylethynyl)-3-hydroxyindolin-2-ones from isatins by C–H activation of arylacetylenes using a catalytic quantity of copper(I) iodide (5 mol%) and DBU (20 mol%) at 25 °C, affording the products in excellent yields in very short reaction time (5 min).
Key words
catalysis - C–H activation - copper(I) iodide - arylalkyne addition - 3-hydroxyindolin-2-onesSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis. Included are scanned spectra (IR, 1H NMR, 13C NMR and HRMS).
- Supporting Information
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