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Synthesis 2014; 46(03): 357-367
DOI: 10.1055/s-0033-1338565
DOI: 10.1055/s-0033-1338565
paper
Synthetic Studies towards an Advanced Precursor of the Jatrophane Diterpene Pl-4
Further Information
Publication History
Received: 22 October 2013
Accepted after revision: 31 October 2013
Publication Date:
27 November 2013 (online)
Abstract
Jatrophane diterpenes, isolated from members of the Euphorbiaceae plant family, constitute a class of biologically and structurally intriguing natural products. Herein, different strategies for the preparation of an advanced intermediate towards the total synthesis of the jatrophane diterpene Pl-4 are described. Key strategies for the elaboration of the jatrophane precursors include hydrometalation and radical reactions.
Key words
Euphorbiaceae - jatrophane diterpene - hydrometalation - samarium diiodide - Reformatsky reactionSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis. The experimental procedures and analytical data of all intermediates, described within this manuscript, can be found in the supporting information.
- Supporting Information
-
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