Synthesis of Pyridoacridines through Anionic Cascade Ring Closure

Abstract

A new synthesis of 13-deazaascididemin (AK-37) based on a recently developed anionic cascade ring closure is presented. Although the isolated yields are modest, the approach provides ready access to new substituted derivatives of 13-deazaascididemin.

Key words

fused ring systems - natural products - cross coupling - anionic cascade ring closure - oxidation

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