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Synthesis 2013; 45(12): 1667-1674
DOI: 10.1055/s-0033-1338744
DOI: 10.1055/s-0033-1338744
paper
Synthesis of Isothiocyanates by Reaction of Amines with Phenyl Chlorothionoformate via One-Pot or Two-Step Process
Further Information
Publication History
Received: 26 March 2013
Accepted after revision: 16 April 2013
Publication Date:
08 May 2013 (online)
Abstract
A facile and efficient synthesis of isothiocyanates from amines is described. This method involves the reaction of amines with phenyl chlorothionoformate in the presence of solid sodium hydroxide by either a one-pot process or a two-step approach. The one-pot process is useful for preparing alkyl and electron-rich aryl isothiocyanates, whereas the two-step approach is more versatile, working very well not only for alkyl and electron-rich aryl isothiocyanates, but also for highly electron-deficient aryl and heterocyclic isothiocyanates.
Key words
isothiocyanates - phenyl chlorothionoformate - amine - one-pot process - two-step approachSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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