Gold(I)-Catalyzed Diketonization of Alkynes and Its Application for the One-Pot Synthesis of Quinoxaline Derivatives

Yunkui Liu; Xiaoling Chen; Jian Zhang; Zhenyuan Xu

doi:10.1055/s-0033-1338804

Synlett, Table of Contents

Synlett 2013; 24(11): 1371-1376
DOI: 10.1055/s-0033-1338804

letter

Gold(I)-Catalyzed Diketonization of Alkynes and Its Application for the One-Pot Synthesis of Quinoxaline Derivatives

Yunkui Liu*

State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou, 310014, P. R. of China Fax: +86(571)88320066 Email: ykuiliu@zjut.edu

,

Xiaoling Chen

State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou, 310014, P. R. of China Fax: +86(571)88320066 Email: ykuiliu@zjut.edu

,

Jian Zhang

State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou, 310014, P. R. of China Fax: +86(571)88320066 Email: ykuiliu@zjut.edu

,

Zhenyuan Xu

State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou, 310014, P. R. of China Fax: +86(571)88320066 Email: ykuiliu@zjut.edu

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Abstract

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Abstract

A gold(I)-catalyzed oxidative diketonization of alkynes by water in the presence of Selectfluor has been achieved. The application of the present protocol for the one-pot synthesis of quinoxaline derivatives from alkynes and o-phenylenediamines has also been successful.

Key word

gold catalysis - alkynes - 1,2-diketones - oxidation reactions - quinoxalines

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References

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