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Synthesis 2013; 45(16): 2241-2244
DOI: 10.1055/s-0033-1338909
DOI: 10.1055/s-0033-1338909
paper
Palladium-Catalyzed Reaction of Arylboronic Acids with Aliphatic Nitriles: Synthesis of Alkyl Aryl Ketones and 2-Arylbenzofurans
Further Information
Publication History
Received: 31 March 2013
Accepted after revision: 29 April 2013
Publication Date:
11 June 2013 (online)
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Abstract
An efficient palladium-catalyzed addition of arylboronic acids to aliphatic nitriles has been developed, providing a wide range of alkyl aryl ketones in moderate to excellent yields. It is noteworthy that sequential addition and intramolecular annulation reaction of 2-(2-hydroxyphenyl)acetonitriles with arylboronic acids are also conducted smoothly to afford 2-arylbenzofurans in good yields under the standard conditions.
Key words
palladium - aliphatic nitriles - arylboronic acids - alkyl aryl ketones - 2-arylbenzofuransSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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