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Synthesis 2014; 46(14): 1938-1946
DOI: 10.1055/s-0033-1339128
DOI: 10.1055/s-0033-1339128
special topic
Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates
Further Information
Publication History
Received: 28 February 2014
Accepted after revision: 05 May 2014
Publication Date:
12 June 2014 (online)
Abstract
The development of efficient methods for accessing fluorinated functional groups is desirable. Herein, we report a two-step method that utilizes catalytic copper for the decarboxylative trifluoromethylation of propargyl bromodifluoroacetates is described. This protocol affords a mixture of propargyl trifluoromethanes and trifluoromethyl allenes.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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