Improved Catalyst-Free Synthesis of Pyrrole Derivatives in Aqueous Media

Fatemeh Tamaddon; Farideh Amirpoor

doi:10.1055/s-0033-1339294

Synlett, Table of Contents

Synlett 2013; 24(14): 1791-1794
DOI: 10.1055/s-0033-1339294

letter

Improved Catalyst-Free Synthesis of Pyrrole Derivatives in Aqueous Media

Fatemeh Tamaddon*

Department of Chemistry, Faculty of Science, Yazd University, Yazd 89195-741, Iran Fax: +98(351)8210664 Email: ftamaddon@yazduni.ac.ir

,

Farideh Amirpoor

Department of Chemistry, Faculty of Science, Yazd University, Yazd 89195-741, Iran Fax: +98(351)8210664 Email: ftamaddon@yazduni.ac.ir

› Author Affiliations

Abstract

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Abstract

An improved catalyst-free, three-component reaction of ammonium acetate, 1,3-dicarbonyl compounds, and aromatic α-hydroxycarbonyl compounds has been carried out in water–ethanol (50:50) under reflux conditions. The improvement of yield in this aqueous medium is attributed to a combination of increased association of the reactants by hydrophobic interactions and precipitation of the product during the reaction. This operationally simple procedure is less laborious and provides a better scope and chemoselectivity than previously reported procedures.

Key words

catalyst-free - multicomponent reaction - aqueous medium - pyrrole derivatives - α-hydroxycarbonyl compounds

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References

References and Notes
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