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Synlett 2013; 24(14): 1795-1800
DOI: 10.1055/s-0033-1339466
DOI: 10.1055/s-0033-1339466
letter
One-Pot Regioselective Synthesis of Imidazole and 2,3-Dihydroquinazolinone Derivatives – An Easy Access to ‘Nature-Like Molecules’; Part XIII in the Series: ‘Studies on Novel Synthetic Methodologies’
Further Information
Publication History
Received: 15 April 2013
Accepted after revision: 21 June 2013
Publication Date:
01 August 2013 (online)
![](https://www.thieme-connect.de/media/synlett/201314/lookinside/thumbnails/10.1055-s-0033-1339466-1.jpg)
Abstract
A mild and highly practical regioselective synthesis of imidazole and 2,3-dihydroquinazolinone derivatives from 5-alkyl-4-hydroxyisophthalaldehydes with suitable substrates in acetic acid is reported. Further exploration of the molecular diversity of 2,3-dihydroquinazolinone is demonstrated by the synthesis of diverse pharmacologically relevant natural-product-like scaffolds.
Key words
one-pot synthesis - regioselective synthesis - imidazole - 2,3-dihydroquinazolinone - 5-alkyl-4-hydroxyisophthalaldehydes - nature-like moleculesSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
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References and Notes
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