One-Pot Regioselective Synthesis of Imidazole and 2,3-Dihydroquinazolinone Derivatives – An Easy Access to ‘Nature-Like Molecules’; Part XIII in the Series: ‘Studies on Novel Synthetic Methodologies’

Abstract

A mild and highly practical regioselective synthesis of imidazole and 2,3-dihydroquinazolinone derivatives from 5-alkyl-4-hydroxyisophthalaldehydes with suitable substrates in acetic acid is reported. Further exploration of the molecular diversity of 2,3-dihydroquinazolinone is demonstrated by the synthesis of diverse pharmacologically relevant natural-product-like scaffolds.

Key words

one-pot synthesis - regioselective synthesis - imidazole - 2,3-dihydroquinazolinone - 5-alkyl-4-hydroxyisophthalaldehydes - nature-like molecules

• References and Notes

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