Solvent- and Ligand-Free Palladium-Catalyzed Amination of Aryl Halides

Luca Basolo; Alice Bernasconi; Gianluigi Broggini; Silvia Gazzola; Egle M. Beccalli

doi:10.1055/s-0033-1339659

Synthesis, Table of Contents

Synthesis 2013; 45(22): 3151-3156
DOI: 10.1055/s-0033-1339659

paper

Solvent- and Ligand-Free Palladium-Catalyzed Amination of Aryl Halides

Luca Basolo

^aDISFARM, Sezione di Chimica Generale e Organica ‘A. Marchesini’ Università degli Studi di Milano, via Venezian 21, 20133 Milano, Italy Fax: +39(02)50314476 Email: egle.beccalli@unimi.it

,

Alice Bernasconi

^aDISFARM, Sezione di Chimica Generale e Organica ‘A. Marchesini’ Università degli Studi di Milano, via Venezian 21, 20133 Milano, Italy Fax: +39(02)50314476 Email: egle.beccalli@unimi.it

,

Gianluigi Broggini

^bDipartimento di Scienza e Alta Tecnologia, Università dell’Insubria, via Valleggio 11, 22100 Como, Italy Email: gianluigi.broggini@uninsubria.it

,

Silvia Gazzola

^bDipartimento di Scienza e Alta Tecnologia, Università dell’Insubria, via Valleggio 11, 22100 Como, Italy Email: gianluigi.broggini@uninsubria.it

,

Egle M. Beccalli*

^aDISFARM, Sezione di Chimica Generale e Organica ‘A. Marchesini’ Università degli Studi di Milano, via Venezian 21, 20133 Milano, Italy Fax: +39(02)50314476 Email: egle.beccalli@unimi.it

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Abstract

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Abstract

An environmentally friendly and economically favorable approach to the formation of C–N bonds is presented. The methodology is particularly interesting in that the reaction is realized under both solvent- and ligand-free conditions and involves the use of a low loading of a palladium catalyst dispersed with the reactants on a suitable solid support. The reaction proceeds rapidly under microwave irradiation.

Key words

arylation - amination - catalysis - solid-phase synthesis - green-chemistry - microwave

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References

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