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Synthesis 2013; 45(21): 3038-3043
DOI: 10.1055/s-0033-1339682
DOI: 10.1055/s-0033-1339682
paper
Anti-Friedel–Crafts-Type Substitution To Form Biaryl Linkages
Further Information
Publication History
Received: 19 June 2013
Accepted after revision: 08 August 2013
Publication Date:
02 September 2013 (online)
Abstract
The ipso-substitution of one (or two) hydroxy groups of phloroglucinol with arene nucleophiles (e.g., o-xylene, tetralin, biphenyl) can be achieved easily under Friedel–Crafts-type conditions with or without the use of organic solvents affording a variety of 3,5-dihydroxybiphenyls (57–89% yields). The new method has significant practical advantages compared to classical biaryl-coupling routes.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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