Asymmetric Synthesis of α-Aminophosphonate Esters by the Addition of Dialkyl Phosphites to tert-Butanesulfinyl Imines

Abstract

The KHMDS-mediated addition of dialkyl phosphites to N-tert-butanesulfinyl aldimines and ketimines proceeds in uniformly high yields and diastereoselectivities and thereby enables the rapid and general asymmetric synthesis of α-aminophosphonate esters.

Key words

asymmetric synthesis - imines - amines - phosphorus - inhibitors

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