Synthesis of 4-Arylquinazolines by Arylation of Quinazolin-4-ones under Mild Conditions

Abstract

An efficient route to 4-arylquinazolines via arylation of quinazolin-4-ones under mild condition is described. The reaction is carried out by the palladium-catalyzed coupling of quinazolin-4-ones with arylboronic acids in the presence of TsCl leading to 4-arylquinazolines in good to excellent yields.

Key words

4-arylquinazoline - arylation - arylboronic acid - quinazolin-4-one

• References


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