NSAID Conjugates with Carnosine and Amino Acids

Sandhyamayee Sahu; Siva S. Panda; Abdullah M. Asiri; Alan R. Katritzky

doi:10.1055/s-0033-1339920

Synthesis, Table of Contents

Synthesis 2013; 45(24): 3369-3374
DOI: 10.1055/s-0033-1339920

paper

NSAID Conjugates with Carnosine and Amino Acids

Sandhyamayee Sahu

^aCenter for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA Fax: +1(352)3929199 Email: katritzky@chem.ufl.edu

,

Siva S. Panda

^aCenter for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA Fax: +1(352)3929199 Email: katritzky@chem.ufl.edu

,

Abdullah M. Asiri

^bChemistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia

^cCenter of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, Jeddah 21589, Saudi Arabia

,

Alan R. Katritzky*

^aCenter for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA Fax: +1(352)3929199 Email: katritzky@chem.ufl.edu

^bChemistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia

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Abstract

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Abstract

Benzotriazole-mediated syntheses of novel bioconjugates of nonsteroidal anti-inflammatory drugs with carnosine and with amino acids were prepared in yields of 50–97% as potential drug candidates.

Key words

NSAIDs - carnosine - amino acid - prodrug - conjugates - coupling - benzotriazole methodology

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References

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