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Synthesis 2014; 46(02): 258-262
DOI: 10.1055/s-0033-1340085
DOI: 10.1055/s-0033-1340085
paper
Multicomponent Synthesis of Novel Penta-Heterocyclic Ring Systems Incorporating a Benzopyranopyridine Scaffold
Further Information
Publication History
Received: 02 September 2013
Accepted after revision: 10 October 2013
Publication Date:
07 November 2013 (online)
Abstract
A simple one-pot method is reported for the synthesis of several novel series of chromeno[4′,3′:4,5]pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-6,14-diones, chromeno[4′,3′:4,5]pyrido[2,3-d]thiazolo[3,2-a]pyrimidine-6,14-diones, and chrom-eno[4′′,3′′:4′,5′]pyrido[2′,3′:4,5]pyrimido[2,1-b][1,3]thiazine-6,15-dione by a multicomponent reaction of salicylaldehyde, ethyl acetoacetate, and the appropriate fused heterocyclic amines in refluxing glacial acetic acid. The structures of the newly synthesized compounds were established by spectroscopy and elemental analyses. The mechanism of the single-step reaction was elucidated.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
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