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Synthesis 2014; 46(02): 230-234
DOI: 10.1055/s-0033-1340142
paper
© Georg Thieme Verlag Stuttgart · New York

Solvent-Free, Base-Free Microwave-Mediated Iridium-Catalyzed N-Alkylation of Amides with Alcohols

Tushar D. Apsunde
Department of Chemistry, University of New Orleans, New Orleans, LA 70148, USA   Fax: +1(504)2806860   eMail: mtrudell@uno.edu
,
Mark L. Trudell*
Department of Chemistry, University of New Orleans, New Orleans, LA 70148, USA   Fax: +1(504)2806860   eMail: mtrudell@uno.edu
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Publikationsverlauf

Received: 20. September 2013

Accepted: 17. Oktober 2013

Publikationsdatum:
22. November 2013 (online)

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Abstract

Solvent-free, base-free microwave-mediated (Cp*IrCl2)2-catalyzed conditions for the N-alkylation of amides with alcohols have been developed. A series of primary and secondary alcohols have been shown to produce high yields of N-alkyl arylamides and N-alkyl alkylamides.

Key words

alcohol - alkylation - amide - iridium

Supporting Information

    for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
  • Supporting Information
 

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