Synthesis 2014; 46(02): 235-241
DOI: 10.1055/s-0033-1340249
paper
© Georg Thieme Verlag Stuttgart · New York

Unexpected Heteroannulation and Chlorination of Benzothiadiazine Derivatives Mediated by DDQ

Valerie Verones
Laboratoire de Chimie Thérapeutique, UFR Pharmacie Univ Lille Nord de France, 59000 Lille, France   Fax: +33(3)20964913   Email: nicolas.lebegue@univ-lille2.fr
,
Nathalie Flouquet
Laboratoire de Chimie Thérapeutique, UFR Pharmacie Univ Lille Nord de France, 59000 Lille, France   Fax: +33(3)20964913   Email: nicolas.lebegue@univ-lille2.fr
,
Amaury Farce
Laboratoire de Chimie Thérapeutique, UFR Pharmacie Univ Lille Nord de France, 59000 Lille, France   Fax: +33(3)20964913   Email: nicolas.lebegue@univ-lille2.fr
,
Pascal Berthelot
Laboratoire de Chimie Thérapeutique, UFR Pharmacie Univ Lille Nord de France, 59000 Lille, France   Fax: +33(3)20964913   Email: nicolas.lebegue@univ-lille2.fr
,
Nicolas Lebegue*
Laboratoire de Chimie Thérapeutique, UFR Pharmacie Univ Lille Nord de France, 59000 Lille, France   Fax: +33(3)20964913   Email: nicolas.lebegue@univ-lille2.fr
› Author Affiliations
Further Information

Publication History

Received: 09 September 2013

Accepted after revision: 21 October 2013

Publication Date:
14 November 2013 (online)


Abstract

In the course of studies directed toward the synthesis of new tubulin polymerization inhibitors, several benzothiadiazine derivatives were prepared. The oxidative dehydrogenation reaction with DDQ unexpectedly led to heteroannulation and chlorination of the benzothiadiazine tricycles. A rationale for their formation is proposed.

Supporting Information

 
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