Fe(Cp)₂BF₄: An Efficient Lewis Acid Catalyst for the Aminolysis of Epoxides

Abstract

Ferrocenium tetrafluoroborate [Fe(Cp)₂BF₄] is an efficient Lewis acid catalyst for the aminolysis of aromatic, aliphatic, and cyclic epoxides using aniline and substituted anilines as the nucleophile to provide regioselective β-amino alcohols in 61–97% yields under solvent-free conditions at room temperature. The ring opening of cyclohexene oxide with aliphatic amines gave 2-aminocyclohexanols in 33–98% yields at 60 °C under solvent-free conditions.

Key words

epoxides - ring opening - amino alcohols - Lewis acid - Fe(Cp)₂BF₄

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