Total Synthesis of Aculeatins A, B and D and 6-epi-Aculeatin D via an Asymmetric­ Aldol Approach^[1]

Abstract

Simple and efficient stereoselective total syntheses of aculeatins A, B and D and 6-epi-aculeatin D starting from 1-tetradecanal have been accomplished. The synthesis is based on the Crimmins aldol reaction involving a chiral auxiliary.

Key words

aculeatins - stereoselective total synthesis - Crimmins aldol reaction - chiral auxiliary - spirocyclization

• References

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