Synthesis 2014; 46(09): 1205-1210
DOI: 10.1055/s-0033-1340866
paper
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of Aculeatins A, B and D and 6-epi-Aculeatin D via an Asymmetric­ Aldol Approach[1]

Lingaiah Maram
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India   Fax: +91(40)27193198   eMail: biswanathdas@yahoo.com
,
Biswanath Das*
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India   Fax: +91(40)27193198   eMail: biswanathdas@yahoo.com
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Publikationsverlauf

Received: 23. November 2013

Accepted after revision: 05. Februar 2014

Publikationsdatum:
19. März 2014 (online)


Abstract

Simple and efficient stereoselective total syntheses of aculeatins A, B and D and 6-epi-aculeatin D starting from 1-tetradecanal have been accomplished. The synthesis is based on the Crimmins aldol reaction involving a chiral auxiliary.

Supporting Information