An Efficient Pd/Al(OH)₃ Nanoparticle Catalyst for Suzuki Coupling Reactions of Aryl Halides

Abstract

A high-performance palladium-based Pd/Al(OH)₃ catalyst has been prepared by the one-pot three-component method. It was found that this ‘ligandless’ Pd/Al(OH)₃ catalyst showed remarkable reactivity and gave excellent yields (up to 99%) towards the condensation of aryl bromides with various arylboronic acids under mild conditions, and afforded good yields of the coupling products (up to 97%) with most aryl chlorides in two different catalytic systems. Furthermore, this catalyst could be easily recovered through filtration and reused for 8 cycles without significant loss of the yield.

Key words

Pd/Al(OH)₃ - palladium nanoparticles - Suzuki coupling - cross-coupling - aryl halides

• References

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• 9 To evaluate and compare the catalytic activity of the novel Pd/Al(OH)₃, Al₂O₃-supported Pd/γ-Al₂O₃ nanoparticle catalyst was used for the Suzuki coupling reaction between bromobenzene and phenylboronic acid under the same conditions (see Table 1, entry 9). The result showed that 93% yield was obtained with this Pd/γ-Al₂O₃ catalyst, which demonstrated that the Pd/Al(OH)₃ exhibited the same excellent catalytic activity (for the preparation of Pd/γ-Al₂O₃, see Supporting Information)
• 10 The conditions were 0.5 mol% Pd catalyst 1 in K₂CO₃/PEG-400/I₂ system at 140 °C (see Table 6 in Supporting Information), and the results are summarized in Table 4