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Synthesis 2014; 46(11): 1463-1468
DOI: 10.1055/s-0033-1341101
DOI: 10.1055/s-0033-1341101
paper
Facile Direct Synthesis of Acetylenedicarboxamides
Further Information
Publication History
Received: 13 January 2014
Accepted after revision: 11 February 2014
Publication Date:
17 March 2014 (online)
Abstract
A convenient, rapid and widely applicable one-pot procedure has been developed for the synthesis of acetylenedicarboxamides from various primary and secondary amines, including amino acid derivatives, protected carbohydrates, and fluorescent labels. By using DMTMM for amide coupling, acetylenedicarboxylic acid was directly converted into acetylenedicarboxamides in highly competitive overall yields (52–80%).
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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