An Efficient Synthesis of Nitrated Cycloalka[b]pyridines

Abstract

The three-component ring transformation of 1-methyl-3,5-dinitro-2-pyridone with cycloalkanones of different ring sizes in the presence of ammonium acetate affords the corresponding nitrated cycloalka[b]pyridines in high yields. Furthermore, a double bond can be easily introduced into the product by changing the cycloalkanone into a cycloalkenone.

Key words

pyridines - multicomponent reaction - ketones - heterocycles - bicyclic compounds - ring transformation

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