Elektrodiagnostische Kriterien der amyotrophen Lateralsklerose

Lernziele

• Stellenwert der Elektrophysiologie in der klinischen Diagnostik der ALS und innerhalb der El Escorial- und Awaji-Diagnosekriterien kennen

• obligate und fakultative Zusatzuntersuchungen bei Verdacht auf ALS unterscheiden können

• Diagnosesicherung, besonders in frühen Stadien

• Literatur

• 1 Brooks BR, Miller RG, Swash M et al. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2000; 1: 293-299
• 2 de Carvalho M, Dengler R, Eisen A et al. Electrodiagnostic criteria for diagnosis of ALS. Clin Neurophysiol 2008; 119: 497-503
• 3 Jaspert A, Claus D, Grehl H et al. Multifocal motor neuropathy: clinical and electrophysiological findings. J Neurol 1996; 243: 684-692
• 4 Mohammadi B, Krampfl K, Kollewe K et al. Correlation between distal motor latency and compound muscle action potential in amyotrophic lateral sclerosis. Neurol Res 2007; 29: 425-428
• 5 de Carvalho M, Chio A, Dengler R et al. Neurophysiological measures in amyotrophic lateral sclerosis: markers of progression in clinical trials. Amyotroph Lateral Scler Other Motor Neuron Disord 2005; 6: 17-28
• 6 Dengler R, Troger M. Classification of ALS – do we know enough?. Amyotroph Lateral Scler Other Motor Neuron Disord 2000; 1: 68-69
• 7 Troger M, Dengler R. The role of electromyography (EMG) in the diagnosis of ALS. Amyotroph Lateral Scler Other Motor Neuron Disord 2000; 1 (Suppl. 02) S33-S40
• 8 Gregory R, Mills K, Donaghy M. Progressive sensory nerve dysfunction in amyotrophic lateral sclerosis: a prospective clinical and neurophysiological study. J Neurol 1993; 240: 309-314
• 9 Pugdahl K, Fuglsang-Frederiksen A, de Carvalho M et al. Generalised sensory system abnormalities in amyotrophic lateral sclerosis: a European multicentre study. J Neurol Neurosurg Psychiatry 2007; 78: 746-749
• 10 Shefner JM, Tyler HR, Krarup C. Abnormalities in the sensory action potential in patients with amyotrophic lateral sclerosis. Muscle Nerve 1991; 14: 1242-1246
• 11 Theys PA, Peeters E, Robberecht W. Evolution of motor and sensory deficits in amyotrophic lateral sclerosis estimated by neurophysiological techniques. J Neurol 1999; 246: 438-442
• 12 Andersen PM, Abrahams S, Borasio GD et al. EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS) – revised report of an EFNS task force. Eur J Neurol 2012; 19: 360-375
• 13 Ludolph AC. Amyotrophe Lateralsklerose (Motoneuronerkrankungen). In: Diener HC, Hrsg. Leitlinien für Diagnostik und Therapie in der Neurologie. Stuttgart, New York: Thieme; 2012: 254-263
• 14 Bischoff C, Dengler R. Vorderhornerkrankungen. In: Bischoff C, Dengler R, Hopf HC, Hrsg. Referenz-Reihe Neurologie – Methoden: EMG – NLG. Stuttgart: Thieme; 2008: 129-130
• 15 Boekestein WA, Kleine BU, Hageman G et al. Sensitivity and specificity of the 'Awaji' electrodiagnostic criteria for amyotrophic lateral sclerosis: retrospective comparison of the Awaji and revised El Escorial criteria for ALS. Amyotroph Lateral Scler 2010; 11: 497-501
• 16 Carvalho MD, Swash M. Awaji diagnostic algorithm increases sensitivity of El Escorial criteria for ALS diagnosis. Amyotroph Lateral Scler 2009; 10, 53-57
• 17 Douglass CP, Kandler RH, Shaw PJ et al. An evaluation of neurophysiological criteria used in the diagnosis of motor neuron disease. J Neurol Neurosurg Psychiatry 2010; 81: 646-649
• 18 Schrooten M, Smetcoren C, Robberecht W et al. Benefit of the Awaji diagnostic algorithm for amyotrophic lateral sclerosis: a prospective study. Ann Neurol 2011; 70: 79-83
• 19 Higashihara M, Sonoo M, Imafuku I et al. Fasciculation potentials in amyotrophic lateral sclerosis and the diagnostic yield of the Awaji algorithm. Muscle Nerve 2012; 45: 175-182
• 20 Hirota N, Eisen A, Weber M. Complex fasciculations and their origin in amyotrophic lateral sclerosis and Kennedy's disease. Muscle Nerve 2000; 23: 1872-1875
• 21 Roth G. The origin of fasciculations. Ann Neurol 1982; 12: 542-547
• 22 Roth G. Fasciculations and their F-response. Localisation of their axonal origin. J Neurol Sci 1984; 63: 299-306
• 23 Wettstein A. The origin of fasciculations in motoneuron disease. Ann Neurol 1979; 5: 295-300
• 24 Chen A, Weimer L, Brannagan III T et al. Experience with the Awaji Island modifications to the ALS diagnostic criteria. Muscle Nerve 2010; 42: 831-832
• 25 Okita T, Nodera H, Shibuta Y et al. Can Awaji ALS criteria provide earlier diagnosis than the revised El Escorial criteria?. J Neurol Sci 2011; 302: 29-32
• 26 Dengler R, Konstanzer A, Hesse S et al. Collateral nerve sprouting and twitch forces of single motor units in conditions with partial denervation in man. Neurosci Lett 1989; 97: 118-122
• 27 Dengler R, Konstanzer A, Kuther G et al. Amyotrophic lateral sclerosis: macro-EMG and twitch forces of single motor units. Muscle Nerve 1990; 13: 545-550
• 28 Payan J. The blanket principle: a technical note. Muscle Nerve 1978; 1: 423-426
• 29 Stalberg EV, Sonoo M. Assessment of variability in the shape of the motor unit action potential, the “jiggle”, at consecutive discharges. Muscle Nerve 1994; 17: 1135-1144
• 30 Dengler R. New Considerations on the Clinical-Neurophysiological Diagnosis of ALS. The “Awaji-Criteria”. Klinische Neurophysiologie 2008; 39: 164-168
• 31 Krarup C. Lower motor neuron involvement examined by quantitative electromyography in amyotrophic lateral sclerosis. Clin Neurophysiol 2011; 122: 414-422
• 32 Noto Y, Misawa S, Kanai K et al. Awaji ALS criteria increase the diagnostic sensitivity in patients with bulbar onset. Clin Neurophysiol 2012; 123: 382-385
• 33 Magistris MR, Rosler KM, Truffert A et al. A clinical study of motor evoked potentials using a triple stimulation technique. Brain 1999; 122: 265-279
• 34 Komissarow L, Rollnik JD, Bogdanova D et al. Triple stimulation technique (TST) in amyotrophic lateral sclerosis. Clin Neurophysiol 2004; 115: 356-360
• 35 Rosler KM, Magistris MR. Triple stimulation technique (TST) in amyotrophic lateral sclerosis. Clin Neurophysiol 2004; 115: 1715
• 36 Urban PP, Vogt T, Hopf HC. Corticobulbar tract involvement in amyotrophic lateral sclerosis. A transcranial magnetic stimulation study. Brain 1998; 121: 1099-1108
• 37 Urban PP, Wicht S, Hopf HC. Sensitivity of transcranial magnetic stimulation of cortico-bulbar vs. cortico-spinal tract involvement in Amyotrophic Lateral Sclerosis (ALS). J Neurol 2001; 248: 850-855
• 38 Chen R, Cros D, Curra A et al. The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol 2008; 119: 504-532
• 39 Claus D, Brunholzl C, Kerling FP et al. Transcranial magnetic stimulation as a diagnostic and prognostic test in amyotrophic lateral sclerosis. J Neurol Sci 1995; 129 (Suppl. 01) 30-34
• 40 Bromberg MB. Updating motor unit number estimation (MUNE). Clin Neurophysiol 2007; 118: 1-8
• 41 Bromberg MB, Brownell AA. Motor unit number estimation in the assessment of performance and function in motor neuron disease. Phys Med Rehabil Clin N Am 2008; 19: 509-532, ix
• 42 Shefner JM, Cudkowicz ME, Zhang H et al. Revised statistical motor unit number estimation in the Celecoxib/ALS trial. Muscle Nerve 2007; 35: 228-234
• 43 Neuwirth C, Weber M. Motor Unit Number Index (MUNIX): ein neuer elektrophysiologischer Marker zur Abschätzung der Anzahl motorischer Einheiten. Klin Neurophysiol 2013; 44: 132-139
• 44 Arts IM, Overeem S, Pillen S et al. Muscle changes in amyotrophic lateral sclerosis: a longitudinal ultrasonography study. Clin Neurophysiol 2011; 122: 623-628
• 45 Pillen S, Arts IM, Zwarts MJ. Muscle ultrasound in neuromuscular disorders. Muscle Nerve 2008; 37: 679-693
• 46 Reimers CD, Ziemann U, Scheel A et al. Fasciculations: clinical, electromyographic, and ultrasonographic assessment. J Neurol 1996; 243: 579-584
• 47 Walker FO, Donofrio PD, Harpold GJ et al. Sonographic imaging of muscle contraction and fasciculations: a correlation with electromyography. Muscle Nerve 1990; 13: 33-39
• 48 Dengler R. Dynamic muscle ultrasound conquers another domain of needle EMG, the detection of fibrillations. Clin Neurophysiol 2009; 120: 843-844
• 49 Pillen S, Nienhuis M, van Dijk JP et al. Muscles alive: ultrasound detects fibrillations. Clin Neurophysiol 2009; 120: 932-936
• 50 Grimm A, Prell T, Witte OW et al. Muskelultraschall – ein sinnvolles Werkzeug bei der Diagnosestellung der amyotrophen Lateralsklerose. Klin Neurophysiol 2013; 44: 140-144