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Horm Metab Res 2013; 45(08): 605-610
DOI: 10.1055/s-0033-1343450
Humans, Clinical
© Georg Thieme Verlag KG Stuttgart · New York

The Role of Leptinemia State as a Mediator of Inflammation in Obese Adults

A. dos Santos Moraes
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
2   Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
,
L. P. Pisani
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
2   Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
3   Post Graduate Program of Nutrition, Federal University of São Paulo – UNIFESP – São Paulo (SP), Brazil
,
F. C. Corgosinho
3   Post Graduate Program of Nutrition, Federal University of São Paulo – UNIFESP – São Paulo (SP), Brazil
,
L. O. Testa Carvalho
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
2   Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
,
D.C. L. Masquio
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
2   Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
,
G. Jamar
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
2   Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
,
R. B. Sanches
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
2   Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
,
L. M. Oyama
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
2   Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
3   Post Graduate Program of Nutrition, Federal University of São Paulo – UNIFESP – São Paulo (SP), Brazil
,
A. R. Dâmaso
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
2   Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
3   Post Graduate Program of Nutrition, Federal University of São Paulo – UNIFESP – São Paulo (SP), Brazil
4   Department of Biosciences, Federal University of São Paulo – UNIFESP –Santos (SP), Brazil
,
C. Belote
2   Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
,
D. A. Caranti
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
2   Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP – Santos (SP), Brazil
4   Department of Biosciences, Federal University of São Paulo – UNIFESP –Santos (SP), Brazil
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Publikationsverlauf

received 24. Oktober 2012

accepted 27. März 2013

Publikationsdatum:
13. Mai 2013 (online)

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Abstract

Hyperleptinemia has emerged as a marker of proinflammatory status, while the adiponectin/leptin ratio has been used to identify anti-inflammatory state. In this context, the aims of the present study were to investigate the role of leptinemia, adjusted by tertiles, on inflammatory state in obese adults according to obesity degree. This is a cross-sectional study comprised of 43 obese adults. The anthropometric variables and body composition were analyzed, as well as markers of inflammation such as leptin, adiponectin, and plasminogen activator inhibitor. Subjects were grouped using adjusted tertiles of the leptin levels. The major finding was the negative correlation between leptin concentration with adiponectin/leptin ratio (r=−0.622, p=0.000) and the positive correlation with leptin/adiponectin ratio (r=0.622, p=0.000). Indeed, both ratios were decreased and increased, respectively, according to the obesity degree. Furthermore, in the stepwise multiple linear regression analysis, the high degree of obesity was an independent predictor of leptinemia when adjusted for age and BMI (β=0.588, p=0.000 and β=0.778, p=0.005). Finally, the strong negatively correlation between the leptinemia with adiponectin/leptin ratio and the positive correlation with leptin/adiponectin ratio reinforce the role of this adipokine as a biomarker of inflammation in obese adults, according to obesity degree. Our findings can elucidate that hyperleptinemic status was a major factor in the proinflammatory status related to higher obesity degree. All together, these data reinforce the role of leptinemia state as a mediator of inflammation in obese adults.

Key words

hyperleptinemia - obesity - body composition - inflammatory status
 

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