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Am J Perinatol 2014; 31(03): 187-194
DOI: 10.1055/s-0033-1343771
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Prenatal Detection of Fetal Growth Restriction in Newborns Classified as Small for Gestational Age: Correlates and Risk of Neonatal Morbidity

Suneet P. Chauhan
1   Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia
,
Hind Beydoun
2   Graduate Program in Public Health, Eastern Virginia Medical School, Norfolk, Virginia
,
Eugene Chang
3   Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina
,
Adam T. Sandlin
4   Department of Obstetrics and Gynecology, University of Arkansas, Little Rock, Arkansas
,
Josh D. Dahlke
5   Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island
,
Elena Igwe
6   Department of Obstetrics and Gynecology, Temple University, Philadelphia, Pennsylvania
,
Everett F. Magann
4   Department of Obstetrics and Gynecology, University of Arkansas, Little Rock, Arkansas
,
Kristi R. Anderson
7   Department of Obstetrics and Gynecology, Naval Medical Center Portsmouth, Portsmouth, Virginia
,
Alfred Z. Abuhamad
1   Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia
,
Cande V. Ananth
8   Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York
9   Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York
› Author Affiliations
Further Information

Publication History

10 January 2013

06 March 2013

Publication Date:
16 April 2013 (online)

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Abstract

We examined the rate of detecting small for gestational age (SGA; birth weight < 10%) as intrauterine growth restriction (IUGR) prenatally at four centers and determined risks of composite neonatal morbidity (CNM) and mortality among detected versus undetected (no antenatal diagnosis of IUGR). A multicenter cohort study of 11,487 nonanomalous, singleton live births with sonographic exam before 22 weeks was performed. Of 11,487 births, 8% (n = 929) were SGA that met the inclusion criteria, with 25% of them being prenatally detected. The CNM among SGA births that were prenatally detected as IUGR was higher (23.3%) than undetected SGA (9.7%), but this difference was no longer significant following adjustments for confounding factors. Among preterm births (< 37 weeks), undetected SGA had significantly higher CNM (risk ratio [RR] 10.0, 95% confidence interval [CI] 6.3, 16.1) for deliveries at 24 to 33 weeks and RR 3.0, 95% CI 1.7, 5.4 for 34 to 36 weeks). In summary, only a quarter of SGA births were detected prenatally as IUGR and among preterm SGA, the CNM is significantly higher when SGA births are undetected as IUGR.

Keywords

small for gestational age - intrauterine growth restriction - composite neonatal morbidity - estimated fetal weight

Presentation Information

Presented at Society of Maternal-Fetal Medicine, Dallas, Texas, United States, February 6 to 11, 2012.


 

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