Download PDF
Aktuelle Dermatologie 2013; 39(08/09): 318-323
DOI: 10.1055/s-0033-1344366
Eine Klinik im Blickpunkt
© Georg Thieme Verlag KG Stuttgart · New York

Histologie des kutanen Lupus erythematodes

Histopathology of Cutaneous Lupus erythematosus
M. Baltaci
Klinik für Dermatologie, HELIOS Klinikum Krefeld
› Author Affiliations
Further Information

Publication History

Publication Date:
24 July 2013 (online)

Also available at
   Permissions and Reprints

Zusammenfassung

Die histologische Untersuchung von Hautveränderungen spielt eine Schlüsselrolle in der Diagnostik des kutanen Lupus erythematodes (LE). LE zeigt ein breites Spektrum histopathologischer Kriterien, das vom Stadium der Läsionen abhängt. Die hauptsächlichen Subtypen des kutanen LE werden beschrieben und die bedeutendsten Differenzialdiagnosen diskutiert.

Abstract

Histologic examination of lesions plays a key role in the diagnostics of cutaneous lupus erythematosus (LE). LE has a broad spectrum of histopathological signs, which are related to the stages of the lesions. Main subtypes of LE are reported and the most considerable histopathologic differential diagnoses are discussed.

 

  • Literatur

  • 1 Sontheimer RD, Thomas JR, Gilliam JN. Subacute cutaneous lupus erythematosus: a cutaneous marker for distinct lupus erythematosus subset. Arch Dermatol 1979; 115: 1409
    CrossrefPubMedGoogle Scholar
  • 2 Gilliam JN, Sontheimer RD. Distinctive cutaneous subsets in the spectrum of lupus erythematosus. J Am Acad Dermatol 1981; 4: 471
    CrossrefPubMedGoogle Scholar
  • 3 Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271
    CrossrefPubMedGoogle Scholar
  • 4 Rothfield N, Sontheimer RD, Bernstein M. Lupus erythematosus: systemic and cutaneous manifestations. Clin Dermatol 2006; 24: 348-362
    CrossrefPubMedGoogle Scholar
  • 5 Watanabe T, Tsuchida T. Classification of lupus erythematosus based upon cutaneous manifestations. Dermatological, systemic and laboratory findings in 191 patients. Dermatology 1995; 190: 277
    CrossrefPubMedGoogle Scholar
  • 6 Ackerman AB, Chongchitnant N, Sanchez J et al. Histologic Diagnosis of Inflammatory Skin Diseases. An Algorithmic Method Based on Pattern Analysis. 2nd. ed., chapter 7. Baltimore: Williams & Wilkins; 1997
    Google Scholar
  • 7 Elder D, Elenitsas R, Jaworsky C, Johnson B. Lever’s Histopathology of the Skin. 8ht. ed., chapter 10. Philadelphia: Lippincott-Raven; 1997
    Google Scholar
  • 8 McKee PH. Pathology of the skin with clinical correlations. Chapter 11. London. Lippincott-Gower; 1989
    Google Scholar
  • 9 Bolognia JL, Jorizzo JL, Rapini RP et al. Dermatology. Volume 1, chapter 43. London: Mosby; 2003
    Google Scholar
  • 10 Freedberg IM, Fitzpatrick TB. Fitzpatrick’s Dermatology in General Medicine. 6th. ed., Vol. 2, chapter 171. McGraw-Hill: New York; 2003
    Google Scholar
  • 11 Zedek DC, Smith Jr ET, Hitchcock MG et al. Cutaneous lupus erythematosus simulating squamous neoplasia: the clinicopathologic conundrum and histopathologic pitfalls. J Am Acad Dermatol 2007; 56: 1013-1020
    CrossrefPubMedGoogle Scholar
  • 12 Bangert JL, Freeman RG, Sontheimer RD et al. Subacute cutaneous lupus erythematosus and discoid lupus erythematosus: comparative histological findings. Arch Dermatol 1984; 120: 332
    CrossrefPubMedGoogle Scholar
  • 13 Crowson AN, Magro C. The cutaneous pathology of lupus erythematosus: a review. J Cutan Pathol 2001; 28: 1-23
    CrossrefPubMedGoogle Scholar
  • 14 Jerdan MS, Hood AF, Moore GW et al. Histopathologic comparison of the subsets of lupus erythematosus. Arch Dermatol 1990; 126: 52
    CrossrefPubMedGoogle Scholar
  • 15 Rowell NR, Swanson-Beck J, Anderson JR. Lupus erythematosus and erythema multiforme-like lesions. Arch Dermatol 1963; 88: 176-180
    CrossrefPubMedGoogle Scholar
  • 16 Shadid NH, Thissen CA, van Marion AM et al. Lupus erythematosus associated with erythema multiforme: Rowell’s syndrome. Int J Dermatol 2007; 46 (Suppl. 03) 30-32
    PubMedGoogle Scholar
  • 17 Lawrence CM, Marshall TL, Byrne JPH. Lupus erythematosus associated with erythema multiforme-like lesions in identical twins. Br J Dermatol 1982; 107: 349-356
    CrossrefPubMedGoogle Scholar
  • 18 Fitzgerald EA, Purcell SM, Kantor GR et al. Rowell’s syndrome: report of a case. Journal of the American Academy of Dermatology 1996; 35: 801-803
    CrossrefPubMedGoogle Scholar
  • 19 Fiallo P, Tagliapietra AG, Santoro G et al. Rowell’s syndrome. International Journal of Dermatology 1995; 34: 635-636
    CrossrefPubMedGoogle Scholar
  • 20 Parodi A, Drago EF, Varaldo G et al. Rowell’s syndrome. Report of a case. Journal of the American Academy of Dermatology 1989; 21: 374-377
    CrossrefPubMedGoogle Scholar
  • 21 Gammon WR, Briggaman RA. Bullous SLE: a phenotypically distinctive but immunologically heterogeneous bullous disorder. J Invest Dermatol 1993; 100: 28S-34S
    CrossrefPubMedGoogle Scholar
  • 22 Yell JA, Allen J, Wojnarowska F et al. Bullous systemic lupus erythematosus: revised criteria for diagnosis. Br J Dermatol 1995; 132: 921
    PubMedGoogle Scholar
  • 23 Kuhn A, Sonntag M, Ruzicka T et al. Histopathologic findings in lupus erythematosus tumidus: review of 80 patients. J Am Acad Dermatol 2003; 48: 901-908
    CrossrefPubMedGoogle Scholar
  • 24 Alexiades-Armenakas MR, Baldassano M, Bince B et al. Tumid lupus erythematosus: criteria for classification with immunohistochemical analysis. Arthritis Rheum 2003; 49: 494-500
    CrossrefPubMedGoogle Scholar
  • 25 Vieira V, Del Pozo J, Yebra-Pimentel MT et al. Lupus erythematosus tumidus: a series of 26 cases. Int J Dermatol 2006; 45: 512-17
    CrossrefPubMedGoogle Scholar
  • 26 Rémy-Leroux V, Léonard F, Lambert D et al. Comparison of histopathologic-clinical characteristics of Jessner’s lymphocytic infiltration of the skin and lupus erythematosus tumidus: Multicenter study of 46 cases. J Am Acad Dermatol 2008; 58: 217-23
    CrossrefPubMedGoogle Scholar
  • 27 Millard LG, Rowell NR. Chilblain lupus erythematosus Hutchinson. Br J Dermatol 1978; 98: 497-506
    CrossrefPubMedGoogle Scholar
  • 28 Cribier B, Djeridi N, Peltre B et al. A histologic and immunohistochemical study of chilblains. J Am Acad Dermatol 2001; 45: 924-929
    CrossrefPubMedGoogle Scholar
  • 29 Daldon PE, Macedo de Souza E, Cintra ML. Hypertrophic lupus erythematosus: a clinicopathological study of 14 cases. J Cutan Pathol 2003; 30: 443-448
    CrossrefPubMedGoogle Scholar
  • 30 Uitto J, Santa-Cruz DJ, Eisen AZ et al. Verrucous lesion in patients with discoid lupus erythematosus. Clinical, histopathological and immunofluorescence studies. Br J Dermatol 1978; 98: 507-520
    CrossrefPubMedGoogle Scholar
  • 31 Oliver GF, Winkelmann RK, Muller SA. Lichenoid dermatitis: a clinicopathologic and immunopathologic review of sixty-two cases. J Am Acad Dermatol 1989; 21: 284-292
    CrossrefPubMedGoogle Scholar
  • 32 Peters MS, Su WP. Lupus erythematosus panniculitis. Med Clin North Am 1989; 73: 1113-1126
    PubMedGoogle Scholar