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Endoscopy 2013; 45(12): 1039-1046
DOI: 10.1055/s-0033-1344794
Review
© Georg Thieme Verlag KG Stuttgart · New York

Updating the management of patients with rectal neuroendocrine tumors

Louis de Mestier
1   Department of Hepatogastroenterology and Digestive Oncology, University Hospital Robert-Debré, Reims, France
,
Hedia Brixi
1   Department of Hepatogastroenterology and Digestive Oncology, University Hospital Robert-Debré, Reims, France
,
Rodica Gincul
2   Department of Hepatogastroenterology, Hospital Edouard Herriot, Lyon, France
,
Thierry Ponchon
2   Department of Hepatogastroenterology, Hospital Edouard Herriot, Lyon, France
,
Guillaume Cadiot
1   Department of Hepatogastroenterology and Digestive Oncology, University Hospital Robert-Debré, Reims, France
› Institutsangaben
Weitere Informationen

Publikationsverlauf

submitted 30. Januar 2013

accepted after revision 11. Juli 2013

Publikationsdatum:
25. Oktober 2013 (online)

Auch verfügbar auf
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Rectal neuroendocrine tumors (NETs) account for approximately one-third of all digestive NETs, with an increasing incidence and good overall prognosis. Although recent guidelines have been published, endoscopic techniques have expanded substantially and the most recent reports should be taken into account for clinical practice. The objectives of this report were to review the latest advances on prognosis, pre-interventional explorations, treatment – with particular focus on endoscopy – and surveillance of well-differentiated rectal NETs, excluding poorly differentiated and metastatic tumors.

 

  • References

  • 1 Yao JC, Hassan M, Phan A et al. One hundred years after “Carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 2008; 26: 3063-3072
    CrossrefPubMedGoogle Scholar
  • 2 Tsikitis VL, Wertheim BC, Guerrero MA. Trends of incidence and survival of gastrointestinal neuroendocrine tumors in the United States: a SEER analysis. J Cancer 2012; 3: 292-302
    CrossrefPubMedGoogle Scholar
  • 3 Avenel P, McKendrick A, Silapaswan S et al. Gastrointestinal carcinoids: an increasing incidence of rectal distribution. Am Surg 2010; 76: 759-763
    PubMedGoogle Scholar
  • 4 Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer 2003; 97: 934-959
    CrossrefPubMedGoogle Scholar
  • 5 Balmadrid BL, Thomas CM, Coffman CJ et al. Factors associated with survival of veterans with gastrointestinal neuroendocrine tumors. J Cancer Epidemiol 2012; 2012: 986708
    PubMedGoogle Scholar
  • 6 Frilling A, Akerström G, Falconi M et al. Neuroendocrine tumor disease: an evolving landscape. Endocr Relat Cancer 2012; 19: R163-R185
    CrossrefPubMedGoogle Scholar
  • 7 Caplin M, Sundin A, Nillson O et al. ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: colorectal neuroendocrine neoplasms. Neuroendocrinology 2012; 95: 88-97
    CrossrefPubMedGoogle Scholar
  • 8 Landry CS, Brock G, Scoggins CR et al. A proposed staging system for rectal carcinoid tumors based on an analysis of 4701 patients. Surgery 2008; 144: 460-466
    CrossrefPubMedGoogle Scholar
  • 9 Niederle MB, Hackl M, Kaserer K et al. Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters. Endocr Relat Cancer 2010; 17: 909-918
    CrossrefPubMedGoogle Scholar
  • 10 Ito T, Sasano H, Tanaka M et al. Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan. J Gastroenterol 2010; 45: 234-243
    CrossrefPubMedGoogle Scholar
  • 11 Cho MY, Kim JM, Sohn JH et al. Current trends of the incidence and pathological diagnosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Korea 2000–2009: multicenter study. Cancer Res Treat 2012; 44: 157-165
    CrossrefPubMedGoogle Scholar
  • 12 Konishi T, Watanabe T, Kishimoto J et al. Prognosis and risk factors of metastasis in colorectal carcinoids: results of a nationwide registry over 15 years. Gut 2007; 56: 863-868
    CrossrefPubMedGoogle Scholar
  • 13 Scherübl H, Jensen RT, Cadiot G et al. Management of early gastrointestinal neuroendocrine neoplasms. World J Gastrointest Endosc 2011; 3: 133-139
    CrossrefPubMedGoogle Scholar
  • 14 Shields CJ, Tiret E, Winter DC. Carcinoid tumors of the rectum: a multi-institutional international collaboration. Ann Surg 2010; 252: 750-755
    CrossrefPubMedGoogle Scholar
  • 15 Fahy BN, Tang LH, Klimstra D et al. Carcinoid of the rectum risk stratification (CaRRs): a strategy for preoperative outcome assessment. Ann Surg Oncol 2007; 14: 1735-1743
    CrossrefPubMedGoogle Scholar
  • 16 Park CH, Cheon JH, Kim JO et al. Criteria for decision making after endoscopic resection of well-differentiated rectal carcinoids with regard to potential lymphatic spread. Endoscopy 2011; 43: 790-795
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 17 Holinga J, Khalid A, Fasanella K et al. Metastatic risk of diminutive rectal carcinoid tumors: a need for surveillance rectal ultrasound?. Gastrointest Endosc 2012; 75: 913-916
    CrossrefPubMedGoogle Scholar
  • 18 Fujimoto Y, Oya M, Kuroyanagi H et al. Lymph-node metastases in rectal carcinoids. Langenbecks Arch Surg 2010; 395: 139-142
    CrossrefPubMedGoogle Scholar
  • 19 Konishi T, Watanabe T, Nagawa H et al. Treatment of colorectal carcinoids: a new paradigm. World J Gastrointest Surg 2010; 2: 153-156
    CrossrefPubMedGoogle Scholar
  • 20 Wang M, Peng J, Yang W et al. Prognostic analysis for carcinoid tumors of the rectum: a single institutional analysis of 106 patients. Colorectal Dis 2011; 13: 150-153
    CrossrefPubMedGoogle Scholar
  • 21 Kasuga A, Chino A, Uragami N et al. Treatment strategy for rectal carcinoids: a clinicopathological analysis of 229 cases at a single cancer institution. J Gastroenterol Hepatol 2012; 27: 1801-1807
    CrossrefPubMedGoogle Scholar
  • 22 Soga J. Early-stage carcinoids of the gastrointestinal tract: an analysis of 1914 reported cases. Cancer 2005; 103: 1587-1595
    CrossrefPubMedGoogle Scholar
  • 23 Kobayashi K, Katsumata T, Yoshizawa S et al. Indications of endoscopic polypectomy for rectal carcinoid tumors and clinical usefulness of endoscopic ultrasonography. Dis Colon Rectum 2005; 48: 285-291
    CrossrefPubMedGoogle Scholar
  • 24 Ishii N, Horiki N, Itoh T et al. Endoscopic submucosal dissection and preoperative assessment with endoscopic ultrasonography for the treatment of rectal carcinoid tumors. Surg Endosc 2010; 24: 1413-1419
    CrossrefPubMedGoogle Scholar
  • 25 Son HJ, Sohn DK, Hong CW et al. Factors associated with complete local excision of small rectal carcinoid tumor. Int J Colorectal Dis 2013; 28: 57-61
    CrossrefPubMedGoogle Scholar
  • 26 Abe T, Kakemura T, Fujinuma S et al. Successful outcomes of EMR-L with 3D-EUS for rectal carcinoids compared with historical controls. World J Gastroenterol 2008; 14: 4054-4058
    CrossrefPubMedGoogle Scholar
  • 27 Iishi H, Tatsuta M, Yano H et al. More effective endoscopic resection with a two-channel colonoscope for carcinoid tumors of the rectum. Dis Colon Rectum 1996; 39: 1438-1439
    CrossrefPubMedGoogle Scholar
  • 28 Kwaan MR, Goldberg JE, Bleday R. Rectal carcinoid tumors: review of results after endoscopic and surgical therapy. Arch Surg 2008; 143: 471-475
    CrossrefPubMedGoogle Scholar
  • 29 Imada-Shirakata Y, Sakai M, Kajiyama T et al. Endoscopic resection of rectal carcinoid tumors using aspiration lumpectomy. Endoscopy 1997; 29: 34-38
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 30 Oshitani N, Hamasaki N, Sawa Y et al. Endoscopic resection of small rectal carcinoid tumours using an aspiration method with a transparent overcap. J Int Med Res 2000; 28: 241-246
    CrossrefPubMedGoogle Scholar
  • 31 Nagai T, Torishima R, Nakashima H et al. Saline-assisted endoscopic resection of rectal carcinoids: cap aspiration method versus simple snare resection. Endoscopy 2004; 36: 202-205
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 32 Kim YJ, Lee SK, Cheon JH et al. [Efficacy of endoscopic resection for small rectal carcinoid: a retrospective study]. Korean J Gastroenterol 2008; 51: 174-180
    PubMedGoogle Scholar
  • 33 Zhao ZF, Zhang N, Ma SR et al. A comparative study on endoscopy treatment in rectal carcinoid tumors. Surg Laparosc Endosc Percutan Tech 2012; 22: 260-263
    CrossrefPubMedGoogle Scholar
  • 34 Koyama N, Yoshida H, Nihei M et al. Endoscopic resection of rectal carcinoids using double snare polypectomy technique. Dig Endosc 1998; 10: 42-45
    CrossrefPubMedGoogle Scholar
  • 35 Berkelhammer C, Jasper I, Kirvaitis E et al. “Band-snare” resection of small rectal carcinoid tumors. Gastrointest Endosc 1999; 50: 582-585
    CrossrefPubMedGoogle Scholar
  • 36 Ono A, Fujii T, Saito Y et al. Endoscopic submucosal resection of rectal carcinoid tumors with a ligation device. Gastrointest Endosc 2003; 57: 583-587
    CrossrefPubMedGoogle Scholar
  • 37 Moon JH, Kim JH, Park CH et al. Endoscopic submucosal resection with double ligation technique for treatment of small rectal carcinoid tumors. Endoscopy 2006; 38: 511-514
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 38 Mashimo Y, Matsuda T, Uraoka T et al. Endoscopic submucosal resection with a ligation device is an effective and safe treatment for carcinoid tumors in the lower rectum. J Gastroenterol Hepatol 2008; 23: 218-221
    CrossrefPubMedGoogle Scholar
  • 39 Onozato Y, Kakizaki S, Iizuka H et al. Endoscopic treatment of rectal carcinoid tumors. Dis Colon Rectum 2010; 53: 169-176
    CrossrefPubMedGoogle Scholar
  • 40 Lee SH, Park SJ, Kim HH et al. Endoscopic resection for rectal carcinoid tumors: comparison of polypectomy and endoscopic submucosal resection with band ligation. Clin Endosc 2012; 45: 89-94
    CrossrefPubMedGoogle Scholar
  • 41 Kim HH, Park SJ, Lee SH et al. Efficacy of endoscopic submucosal resection with a ligation device for removing small rectal carcinoid tumors compared with endoscopic mucosal resection: analysis of 100 cases. Dig Endosc 2012; 24: 159-163
    PubMedGoogle Scholar
  • 42 Niimi K, Goto O, Fujishiro M et al. Endoscopic mucosal resection with a ligation device or endoscopic submucosal dissection for rectal carcinoid tumors: an analysis of 24 consecutive cases. Dig Endosc 2012; 24: 443-447
    CrossrefPubMedGoogle Scholar
  • 43 Kim KM, Eo SJ, Shim SG et al. Treatment outcomes according to endoscopic treatment modalities for rectal carcinoid tumors. Clin Res Hepatol Gastroenterol 2013; 37: 275-282
    CrossrefPubMedGoogle Scholar
  • 44 Park HW, Byeon JS, Park YS et al. Endoscopic submucosal dissection for treatment of rectal carcinoid tumors. Gastrointest Endosc 2010; 72: 143-149
    CrossrefPubMedGoogle Scholar
  • 45 Lee DS, Jeon SW, Park SY et al. The feasibility of endoscopic submucosal dissection for rectal carcinoid tumors: comparison with endoscopic mucosal resection. Endoscopy 2010; 42: 647-651
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 46 Yamaguchi N, Isomoto H, Nishiyama H et al. Endoscopic submucosal dissection for rectal carcinoid tumors. Surg Endosc 2010; 24: 504-508
    CrossrefPubMedGoogle Scholar
  • 47 Zhou PH, Yao LQ, Qin XY et al. Advantages of endoscopic submucosal dissection with needle-knife over endoscopic mucosal resection for small rectal carcinoid tumors: a retrospective study. Surg Endosc 2010; 24: 2607-2612
    CrossrefPubMedGoogle Scholar
  • 48 Suzuki S, Ishii N, Uemura M et al. Endoscopic submucosal dissection (ESD) for gastrointestinal carcinoid tumors. Surg Endosc 2012; 26: 759-763
    CrossrefPubMedGoogle Scholar
  • 49 Kajiyama T, Hajiro K, Sakai M et al. Endoscopic resection of gastrointestinal submucosal lesions: a comparison between strip biopsy and aspiration lumpectomy. Gastrointest Endosc 1996; 44: 404-410
    CrossrefPubMedGoogle Scholar
  • 50 Anthony LB, Strosberg JR, Klimstra DS et al. The NANETS consensus guidelines for the diagnosis and management of gastrointestinal neuroendocrine tumors (NETs): well-differentiated NETs of the distal colon and rectum. Pancreas 2010; 39: 767-774
    CrossrefPubMedGoogle Scholar
  • 51 Shida T, Aminaka M, Shirai Y et al. Endoscopic submucosal dissection with a ligation device for the treatment of rectal carcinoid tumor. Endoscopy 2012; 44 Suppl 2: E4-E5
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 52 Jeong WK, Park JW, Choi HS et al. Transanal endoscopic microsurgery for rectal tumors: experience at Korea’s National Cancer Center. Surg Endosc 2009; 23: 2575-2579
    CrossrefPubMedGoogle Scholar
  • 53 Kinoshita T, Kanehira E, Omura K et al. Transanal endoscopic microsurgery in the treatment of rectal carcinoid tumor. Surg Endosc 2007; 21: 970-974
    CrossrefPubMedGoogle Scholar
  • 54 Suzuki H, Furukawa K, Kan H et al. The role of transanal endoscopic microsurgery for rectal tumors. J Nihon Med Sch 2005; 72: 278-284
    CrossrefPubMedGoogle Scholar
  • 55 Kumar AS, Sidani SM, Kolli K et al. Transanal endoscopic microsurgery for rectal carcinoids: the largest reported United States experience. Colorectal Dis 2012; 14: 562-566
    CrossrefPubMedGoogle Scholar
  • 56 Colonoscopy Study Group of Korean Society of Coloproctology. Clinical characteristics of colorectal carcinoid tumors. J Korean Soc Coloproctol 2011; 27: 17-20
    CrossrefPubMedGoogle Scholar
  • 57 Bensoussan M, Lamarque D, Dousset B et al. [What is the place of the endoscopic treatment in the endocrine tumors of the rectum? ]. Gastroenterol Clin Biol 2008; 32: 985-988
    CrossrefPubMedGoogle Scholar
  • 58 Jeon SM, Lee JH, Hong SP et al. Feasibility of salvage endoscopic mucosal resection by using a cap for remnant rectal carcinoids after primary EMR. Gastrointest Endosc 2011; 73: 1009-1014
    CrossrefPubMedGoogle Scholar
  • 59 Hurlstone DP, Shorthouse AJ, Brown SR et al. Salvage endoscopic submucosal dissection for residual or local recurrent intraepithelial neoplasia in the colorectum: a prospective analysis. Colorectal Dis 2008; 10: 891-897
    PubMedGoogle Scholar
  • 60 Merg A, Wirtzfeld D, Wang J et al. Viability of endoscopic and excisional treatment of early rectal carcinoids. J Gastrointest Surg 2007; 11: 893-897
    CrossrefPubMedGoogle Scholar