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Semin Reprod Med 2013; 31(04): 293-300
DOI: 10.1055/s-0033-1345277
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Nutrient Supplementation: Improving Male Fertility Fourfold

Cesar Mora-Esteves
1   Division of Urology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey
,
David Shin
2   Department of Urology, Hackensack University Medical Center, Hackensack, New Jersey
› Author Affiliations
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Publication History

Publication Date:
17 June 2013 (online)

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Abstract

Oxidative stress can contribute to impairment in spermatogenesis leading to male-factor infertility. The effectiveness of various antioxidants (such as carnitine, vitamin C, vitamin E, selenium, carotenoids, glutathione, N-acetylcysteine, zinc, folic acid, and coenzyme Q10) is variable with respect to improving semen parameters and pregnancy rates. A recent Cochrane review determined that men taking antioxidants had a statistically significant increase in both live birth rates and pregnancy rates. For those undergoing assisted reproduction, the odds ratio that antioxidant use would improve pregnancy rates was 4.18, with a 4.85-fold improvement in live birth rate also noted. Further investigation with randomized, controlled clinical trials is needed to confirm the safety and efficacy of antioxidant supplementation in the medical management and treatment of male infertility.

Keywords

male infertility - antioxidant therapy - vitamin supplements - oxidative stress
 

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