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Semin Respir Crit Care Med 2013; 34(03): 421-430
DOI: 10.1055/s-0033-1348470
DOI: 10.1055/s-0033-1348470
Quality of Life in Lung Transplantation
Further Information
Publication History
Publication Date:
02 July 2013 (online)
Abstract
Improving health-related quality of life is an important goal of lung transplantation. This review describes background concepts, including definitions, measurement and interpretation of health-related quality of life (HRQL), and other patient-reported outcomes. Lung transplantation is associated with dramatic and sustained improvements in HRQL, particularly in measures of physical health and functioning. Physical rehabilitation may augment the early improvements in HRQL, whereas bronchiolitis obliterans syndrome and psychological conditions have a negative impact. More research is needed, particularly longitudinal, multicenter studies, to better understand the trajectory and determinants of HRQL after lung transplantation, and the impact of targeted interventions to improve HRQL.
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References
- 1 Measuring quality of life. 1997. http://www.who.int/mental_health/media/68.pdf
- 2 Orens JB, Estenne M, Arcasoy S , et al; Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation. International guidelines for the selection of lung transplant candidates: 2006 update—a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant 2006; 25 (7) 745-755
- 3 Yusen RD. Technology and outcomes assessment in lung transplantation. Proc Am Thorac Soc 2009; 6 (1) 128-136
- 4 Gosselink R, Troosters T, Decramer M. Peripheral muscle weakness contributes to exercise limitation in COPD. Am J Respir Crit Care Med 1996; 153 (3) 976-980
- 5 O'Donnell DE, Hernandez P, Kaplan A , et al. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2008 update - highlights for primary care. Can Respir J 2008; 15 (15, Suppl A): 1A-8A
- 6 Doward LC, McKenna SP. Defining patient-reported outcomes. Value Health 2004; 7 (Suppl. 01) S4-S8
- 7 Fletcher CM, Elmes PC, Fairbairn AS, Wood CH. The significance of respiratory symptoms and the diagnosis of chronic bronchitis in a working population. BMJ 1959; 2 (5147) 257-266
- 8 Mahler DA, Weinberg DH, Wells CK, Feinstein AR. The measurement of dyspnea: contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest 1984; 85 (6) 751-758
- 9 Eakin EG, Resnikoff PM, Prewitt LM, Ries AL, Kaplan RM. Validation of a new dyspnea measure: the UCSD Shortness of Breath Questionnaire. University of California, San Diego. Chest 1998; 113 (3) 619-624
- 10 McDowell I. Measuring Health: A Guide to Rating Scales and Questionnaires. 3rd ed. New York: Oxford University Press; 2006
- 11 Curtis JR, Martin DP, Martin TR. Patient-assessed health outcomes in chronic lung disease: what are they, how do they help us, and where do we go from here?. Am J Respir Crit Care Med 1997; 156 (4 Pt 1) 1032-1039
- 12 Ware Jr JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36), I: Conceptual framework and item selection. Med Care 1992; 30 (6) 473-483
- 13 Torrance GW. Measurement of health state utilities for economic appraisal. J Health Econ 1986; 5 (1) 1-30
- 14 Singer JP, Chen J, Blanc PD, Leard LE, Kukreja J, Chen H. A thematic analysis of quality of life in lung transplant: the existing evidence and implications for future directions. Am J Transplant 2013; 13 (4) 839-850
- 15 Blough DK, Ramsey S, Sullivan SD, Yusen R. Nett Research Group. The impact of using different imputation methods for missing quality of life scores on the estimation of the cost-effectiveness of lung-volume-reduction surgery. Health Econ 2009; 18 (1) 91-101
- 16 Kugler C, Tegtbur U, Gottlieb J , et al. Health-related quality of life in long-term survivors after heart and lung transplantation: a prospective cohort study. Transplantation 2010; 90 (4) 451-457
- 17 Limbos MM, Joyce DP, Chan CK, Kesten S. Psychological functioning and quality of life in lung transplant candidates and recipients. Chest 2000; 118 (2) 408-416
- 18 O'Brien BJ, Banner NR, Gibson S, Yacoub MH. The Nottingham Health Profile as a measure of quality of life following combined heart and lung transplantation. J Epidemiol Community Health 1988; 42 (3) 232-234
- 19 Ortega T, Deulofeu R, Salamero P , et al; Y Red Temática de Investigatión en Trasplante. Health-related Quality of Life before and after a solid organ transplantation (kidney, liver, and lung) of four Catalonia hospitals. Transplant Proc 2009; 41 (6) 2265-2267
- 20 Ramsey SD, Patrick DL, Lewis S, Albert RK, Raghu G. The University of Washington Medical Center Lung Transplant Study Group. Improvement in quality of life after lung transplantation: a preliminary study. J Heart Lung Transplant 1995; 14 (5) 870-877
- 21 TenVergert EM, Essink-Bot ML, Geertsma A, van Enckevort PJ, de Boer WJ, van der Bij W. The effect of lung transplantation on health-related quality of life: a longitudinal study. Chest 1998; 113 (2) 358-364
- 22 Vasiliadis HM, Collet JP, Poirier C. Health-related quality-of-life determinants in lung transplantation. J Heart Lung Transplant 2006; 25 (2) 226-233
- 23 Vermeulen KM, Groen H, van der Bij W, Erasmus ME, Koëter GH, TenVergert EM. The effect of bronchiolitis obliterans syndrome on health related quality of life. Clin Transplant 2004; 18 (4) 377-383
- 24 Vermeulen KM, TenVergert EM, Verschuuren EAM, Erasmus ME, van der Bij W. Pre-transplant quality of life does not predict survival after lung transplantation. J Heart Lung Transplant 2008; 27 (6) 623-627
- 25 Eskander A, Waddell TK, Faughnan ME, Chowdhury N, Singer LG. BODE index and quality of life in advanced chronic obstructive pulmonary disease before and after lung transplantation. J Heart Lung Transplant 2011; 30 (12) 1334-1341
- 26 Gerbase MW, Soccal PM, Spiliopoulos A, Nicod LP, Rochat T. Long-term health-related quality of life and walking capacity of lung recipients with and without bronchiolitis obliterans syndrome. J Heart Lung Transplant 2008; 27 (8) 898-904
- 27 Gerbase MW, Spiliopoulos A, Rochat T, Archinard M, Nicod LP. Health-related quality of life following single or bilateral lung transplantation: a 7-year comparison to functional outcome. Chest 2005; 128 (3) 1371-1378
- 28 Ihle F, Neurohr C, Huppmann P , et al; Munich Lung Transplant Group. Effect of inpatient rehabilitation on quality of life and exercise capacity in long-term lung transplant survivors: a prospective, randomized study. J Heart Lung Transplant 2011; 30 (8) 912-919
- 29 Kugler C, Strueber M, Tegtbur U, Niedermeyer J, Haverich A. Quality of life 1 year after lung transplantation. Prog Transplant 2004; 14 (4) 331-336
- 30 Stavem K, Bjørtuft O, Lund MB, Kongshaug K, Geiran O, Boe J. Health-related quality of life in lung transplant candidates and recipients. Respiration 2000; 67 (2) 159-165
- 31 Anyanwu AC, McGuire A, Rogers CA, Murday AJ. Assessment of quality of life in lung transplantation using a simple generic tool. Thorax 2001; 56 (3) 218-222
- 32 Busschbach JJ, Horikx PE, van den Bosch JM, Brutel de la Rivière A, de Charro FT. Measuring the quality of life before and after bilateral lung transplantation in patients with cystic fibrosis. Chest 1994; 105 (3) 911-917
- 33 Santana M-J, Feeny D, Johnson JA , et al. Assessing the use of health-related quality of life measures in the routine clinical care of lung-transplant patients. Qual Life Res 2010; 19 (3) 371-379
- 34 Singer LG, Gould MK, Tomlinson G, Theodore J. Determinants of health utility in lung and heart-lung transplant recipients. Am J Transplant 2005; 5 (1) 103-109
- 35 Vasiliadis HM, Collet JP, Penrod JR, Ferraro P, Poirier C. A cost-effectiveness and cost-utility study of lung transplantation. J Heart Lung Transplant 2005; 24 (9) 1275-1283
- 36 Rodrigue JR, Baz MA. Are there sex differences in health-related quality of life after lung transplantation for chronic obstructive pulmonary disease?. J Heart Lung Transplant 2006; 25 (1) 120-125
- 37 Lanuza DM, Lefaiver C, Mc Cabe M, Farcas GA, Garrity Jr E. Prospective study of functional status and quality of life before and after lung transplantation. Chest 2000; 118 (1) 115-122
- 38 Rodrigue JR, Baz MA, Kanasky Jr WF, MacNaughton KL. Does lung transplantation improve health-related quality of life? The University of Florida experience. J Heart Lung Transplant 2005; 24 (6) 755-763
- 39 Cohen J. Statistical Power for the Behavioral Sciences. Hillsdale, NJ: Lawrence Erlbaum; 1988
- 40 Myaskovsky L, Dew MA, McNulty ML , et al. Trajectories of change in quality of life in 12-month survivors of lung or heart transplant. Am J Transplant 2006; 6 (8) 1939-1947
- 41 Finlen Copeland CA, Vock DM, Pieper K, Mark DB, Palmer SM. Impact of lung transplantation on recipient quality of life: a serial, prospective, multicenter analysis through the first posttransplant year. Chest 2013; 143 (3) 744-750
- 42 Munro PE, Holland AE, Bailey M, Button BM, Snell GI. Pulmonary rehabilitation following lung transplantation. Transplant Proc 2009; 41 (1) 292-295
- 43 Pinson CW, Feurer ID, Payne JL, Wise PE, Shockley S, Speroff T. Health-related quality of life after different types of solid organ transplantation. Ann Surg 2000; 232 (4) 597-607
- 44 Ricotti S, Vitulo P, Petrucci L, Oggionni T, Klersy C. Italian Group on QoL in Lung Transplant. Determinants of quality of life after lung transplant: an Italian collaborative study. Monaldi Arch Chest Dis 2006; 65 (1) 5-12
- 45 MacNaughton KL, Rodrigue JR, Cicale M, Staples EM. Health-related quality of life and symptom frequency before and after lung transplantation. Clin Transplant 1998; 12 (4) 320-323
- 46 Gross CR, Savik K, Bolman III RM, Hertz MI. Long-term health status and quality of life outcomes of lung transplant recipients. Chest 1995; 108 (6) 1587-1593
- 47 Santana MJ, Feeny D, Jackson K, Weinkauf J, Lien D. Improvement in health-related quality of life after lung transplantation. Can Respir J 2009; 16 (5) 153-158
- 48 Singer JP, Katz PP, Chen H , et al. Lung transplantation improves health-related quality of life, particularly in those with the poorest status before transplant [abstract]. Chest 2011; 140: 1023A
- 49 TenVergert EM, Vermeulen KM, Geertsma A , et al. Quality of life before and after lung transplantation in patients with emphysema versus other indications. Psychol Rep 2001; 89 (3) 707-717
- 50 Vermeulen KM, van der Bij W, Erasmus ME, Duiverman EJ, Koëter GH, TenVergert EM. Improved quality of life after lung transplantation in individuals with cystic fibrosis. Pediatr Pulmonol 2004; 37 (5) 419-426
- 51 Eskander A, Waddell TK, Faughnan ME, Chowdhury N, Singer LG. BODE index and quality of life in advanced chronic obstructive pulmonary disease before and after lung transplantation. J Heart Lung Transplant 2011; 30 (12) 1334-1341
- 52 Lutogniewska W, Jastrzebski D, Wyrwol J , et al. Dyspnea and quality of life in patients referred for lung transplantation. Eur J Med Res 2010; 15 (Suppl. 02) 76-78
- 53 Smeritschnig B, Jaksch P, Kocher A , et al. Quality of life after lung transplantation: a cross-sectional study. J Heart Lung Transplant 2005; 24 (4) 474-480
- 54 Jones PW. Interpreting thresholds for a clinically significant change in health status in asthma and COPD. Eur Respir J 2002; 19 (3) 398-404
- 55 Celli BR, Cote CG, Marin JM , et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 2004; 350 (10) 1005-1012
- 56 Rutherford RM, Fisher AJ, Hilton C , et al. Functional status and quality of life in patients surviving 10 years after lung transplantation. Am J Transplant 2005; 5 (5) 1099-1104
- 57 Vermeulen KM, Ouwens JP, van der Bij W, de Boer WJ, Koëter GH, TenVergert EM. Long-term quality of life in patients surviving at least 55 months after lung transplantation. Gen Hosp Psychiatry 2003; 25 (2) 95-102
- 58 Egan TM, Murray S, Bustami RT , et al. Development of the new lung allocation system in the United States. Am J Transplant 2006; 6 (5 Pt 2) 1212-1227
- 59 Christie JD, Edwards LB, Kucheryavaya AY , et al; International Society of Heart and Lung Transplantation. The Registry of the International Society for Heart and Lung Transplantation: 29th adult lung and heart-lung transplant report-2012. J Heart Lung Transplant 2012; 31 (10) 1073-1086
- 60 Singer JP, Katz PP, Chen H , et al. Change in Disability is a Determinant of Quality of Life in Persons Undergoing Lung Transplant. J Heart Lung Transplant 2012; 31: S504
- 61 Singer LG, Chowdhury N, Chaparro C, Hutcheon MA. 175: Post-Lung Transplant Health-Related Quality of Life: Perception and Reality. J Heart Lung Transplant 2009; 28: S127
- 62 Kugler C, Fischer S, Gottlieb J , et al. Health-related quality of life in two hundred-eighty lung transplant recipients. J Heart Lung Transplant 2005; 24 (12) 2262-2268
- 63 Künsebeck HW, Kugler C, Fischer S , et al. Quality of life and bronchiolitis obliterans syndrome in patients after lung transplantation. Prog Transplant 2007; 17 (2) 136-141
- 64 van Den Berg JW, Geertsma A, van Der BIJ W , et al. Bronchiolitis obliterans syndrome after lung transplantation and health-related quality of life. Am J Respir Crit Care Med 2000; 161 (6) 1937-1941
- 65 Vermuelen KM, van der Bij W, Erasmus ME, TenVergert EM. Long-term health-related quality of life after lung transplantation: different predictors for different dimensions. J Heart Lung Transplant 2007; 26 (2) 188-193
- 66 Estenne M, Maurer JR, Boehler A , et al. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant 2002; 21 (3) 297-310
- 67 Archonti C, D'Amelio R, Klein T, Schäfers HJ, Sybrecht GW, Wilkens H. [Physical quality of life and social support in patients on the waiting list and after a lung transplantation]. Psychother Psychosom Med Psychol 2004; 54 (1) 17-22
- 68 Cohen L, Littlefield C, Kelly P, Maurer J, Abbey S. Predictors of quality of life and adjustment after lung transplantation. Chest 1998; 113 (3) 633-644
- 69 Stilley CS, Dew MA, Stukas AA , et al. Psychological symptom levels and their correlates in lung and heart-lung transplant recipients. Psychosomatics 1999; 40 (6) 503-509
- 70 Puhan MA, Gimeno-Santos E, Scharplatz M, Troosters T, Walters EH, Steurer J. Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2011; (10) CD005305
- 71 Salhi B, Troosters T, Behaegel M, Joos G, Derom E. Effects of pulmonary rehabilitation in patients with restrictive lung diseases. Chest 2010; 137 (2) 273-279
- 72 Lacasse Y, Goldstein R, Lasserson TJ, Martin S. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2006; (4) CD003793
- 73 McKenna MJ, Fraser SF, Li JL , et al. Impaired muscle Ca2+ and K+ regulation contribute to poor exercise performance post-lung transplantation. J Appl Physiol 2003; 95 (4) 1606-1616
- 74 Mercier JG, Hokanson JF, Brooks GA. Effects of cyclosporine A on skeletal muscle mitochondrial respiration and endurance time in rats. Am J Respir Crit Care Med 1995; 151 (5) 1532-1536
- 75 Bartels MN, Armstrong HF, Gerardo RE , et al. Evaluation of pulmonary function and exercise performance by cardiopulmonary exercise testing before and after lung transplantation. Chest 2011; 140 (6) 1604-1611
- 76 Langer D, Burtin C, Schepers L , et al. Exercise training after lung transplantation improves participation in daily activity: a randomized controlled trial. Am J Transplant 2012; 12 (6) 1584-1592
- 77 DeVito Dabbs A, Dew MA, Myers B , et al. Evaluation of a hand-held, computer-based intervention to promote early self-care behaviors after lung transplant. Clin Transplant 2009; 23 (4) 537-545
- 78 Irani S, Mahler C, Goetzmann L, Russi EW, Boehler A. Lung transplant recipients holding companion animals: impact on physical health and quality of life. Am J Transplant 2006; 6 (2) 404-411
- 79 Matthees BJ, Anantachoti P, Kreitzer MJ, Savik K, Hertz MI, Gross CR. Use of complementary therapies, adherence, and quality of life in lung transplant recipients. Heart Lung 2001; 30 (4) 258-268
- 80 Rodrigue JR, Baz MA. Waiting for lung transplantation: quality of life, mood, caregiving strain and benefit, and social intimacy of spouses. Clin Transplant 2007; 21 (6) 722-727
- 81 Lefaiver CA, Keough VA, Letizia M, Lanuza DM. Quality of life in caregivers providing care for lung transplant candidates. Prog Transplant 2009; 19 (2) 142-152
- 82 Ware Jr J, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care 1996; 34 (3) 220-233
- 83 Chisholm-Burns MA, Spivey CA, Wilks SE. Social support and immunosuppressant therapy adherence among adult renal transplant recipients. Clin Transplant 2010; 24 (3) 312-320
- 84 Dew MA, Switzer GE, DiMartini AF, Matukaitis J, Fitzgerald MG, Kormos RL. Psychosocial assessments and outcomes in organ transplantation. Prog Transplant 2000; 10 (4) 239-259 , quiz 260–261
- 85 Stilley CS, DiMartini AF, de Vera ME , et al. Individual and environmental correlates and predictors of early adherence and outcomes after liver transplantation. Prog Transplant 2010; 20 (1) 58-66 , quiz 67
- 86 Telles-Correia D, Barbosa A, Mega I, Barroso E, Monteiro E. Psychiatric and psychosocial predictors of medical outcome after liver transplantation: a prospective, single-center study. Transplant Proc 2011; 43 (1) 155-157
- 87 Bhinder S, Chowdhury N, Granton J , et al. Feasibility of internet-based health-related quality of life data collection in a large patient cohort. J Med Internet Res 2010; 12 (3) e35
- 88 Benzo R, Farrell MH, Chang CC , et al; NETT Research Group. Integrating health status and survival data: the palliative effect of lung volume reduction surgery. Am J Respir Crit Care Med 2009; 180 (3) 239-246