Structures, Biological Activities and Preliminary Mechanism of Action Studies of Harmful Algal Bloom Toxins from Karlodinium sp.

AL Waters; J Oh; J Peng; AR Place; MT Hamann

doi:10.1055/s-0033-1348538

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Planta Med 2013; 79 - CL13
DOI: 10.1055/s-0033-1348538

Structures, Biological Activities and Preliminary Mechanism of Action Studies of Harmful Algal Bloom Toxins from Karlodinium sp.

AL Waters ¹, J Oh ¹, J Peng ¹, AR Place ², MT Hamann ¹

¹The Department of Pharmacognosy, University of Mississippi, School of Pharmacy, University, Mississippi 38677
²Institute of Marine and Environmental Technology, University of Maryland Center for Environmental Sciences, Suite 236 Columbus Center, Baltimore, Maryland 21202

Congress Abstract

Karlotoxins (KmTx) 2-10 were isolated from the pan-global HAB dinoflagellate species of Karlodinium veneficum and conicum. Due to the contrasting conformational difference between the karlotoxins and closely related amphidinols, the absolute configuration of KmTx is being further evaluated by an integrated degradation/experimental and calculated circular dichroism approach and a crystalline sponge approach. The expanded structure activity relationship of the class along with investigations into the cholesterol binding mechanism of action is being explored with new implications for the treatment of cancer and angiogenesis inhibitors.