Planta Med 2013; 79 - CL17
DOI: 10.1055/s-0033-1348542

Isolation of Rotenoids from the Fruits of Millettia caerulea

L Bueno Pérez 1, L Pan 1, DD Lantvit 2, T Ngoc Ninh 3, HB Chai 1, JC Gallucci 4, SM Swanson 2, DD Soejarto 2, AD Kinghorn 1
  • 1Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
  • 2Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
  • 3Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Hanoi, Vietnam
  • 4Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA

One novel (1), two new (2 and 3), and nine known (4 – 12) rotenoids were isolated from Millettia caerulea (Graham) Baker (Fabaceae) collected in Vietnam. The structure of 1 was confirmed by X-ray diffraction analysis. Compounds 4 and 5 exhibited IC50 values of 0.3 and 0.1µM, respectively, against the HT-29 human colon cancer cell line and were non-toxic to CCD-112CoN normal colon cells. cis-(6aβ,12aβ)-Hydroxyrotenone (5) was tested in an in vivo hollow fiber assay using three human cancer cell lines.