Planta Med 2013; 79 - PK6
DOI: 10.1055/s-0033-1348630

Cytotoxic Batzelladine L from the Brazilian Marine Sponge Monanchora arbuscula

C Pessoa 1, 2, MFC dos Santos 3, RGS Berlinck 3, PMP Ferreira 4, BC Cavalcanti 1
  • 1Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE
  • 2FIOCRUZ, Fortaleza, CE
  • 3Instituto de Química, Universidade de São Paulo, São Carlos, SP
  • 4Departamento de Ciências Biológicas, Universidade Federal do Piauí, Picos, PI, Brazil

Marine organisms have become an important source of noveland biologically active secondary metabolites. The batzelladines, a class of polycyclic marine alkaloids containing a guanidine group, have been isolated from various sponges' species of the genus Batzella and Monanchora. Diverse biological activities (i.e. antiparasitic, antifungal, and antibacterial) have been reported for these alkaloids. Herein, the cytotoxicity of batzelladine L from M. arbuscula was evaluated against several human cancer cell lines (leukemia, colorectal, breast, melanoma and glioblastoma) through MTT test. After 72h exposure, batzelladine L showed a potent cytotoxic activity on all lines tested with IC50 values below 1 µg/mL and showing lack of selectivity toward cancer cells. Flow cytometry analysis revealed that batzelladine L (3 µg/mL) induced significantly apoptosis through caspase activation and G1 cell cycle arrest in HCT-8 colorectal cancer cells after 24h exposure.

batzelladine L