Planta Med 2013; 79 - PN28
DOI: 10.1055/s-0033-1348709

Bioactive Flavaglines and Other Constituents Isolated from Aglaia perviridis

L Pan 1, U Muñoz Acuña 2, J Li 1, N Jena 1, TN Ninh 3, CM Pannell 4, H Chai 1, JR Fuchs 1, EJ Carcache de Blanco 1, 2, DD Soejarto 5, AD Kinghorn 1
  • 1College of Pharmacy, Division of Medicinal Chemistry and Pharmacognosy
  • 2Division of Pharmacy Practice and Administration, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
  • 3Institute of Ecology and Biological Resources, Vietnamese Academy of Science and Technology, Hanoi, Vietnam
  • 4Department of Plant Sciences, University of Oxford, U. K.
  • 5Program for Collaborative Research in the Pharmaceutical Science and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA

Eight new compounds, including four flavaglines (1 – 4) and four triterpenoids (5 – 8), together with 16 known compounds, were isolated from Aglaia perviridis collected in Vietnam. The new compounds 2 – 4 and seven known rocaglate derivatives (9 – 15) exhibited significant cytotoxicity against the HT-29 cell line. The cytotoxic compounds were further evaluated against a normal colon cell line, CCD-112CoN. In addition, the new compound perviridicin B (2) and four known compounds (9, 11, 12 and 17), showed significant NF-κB (p65) inhibitory activity in an ELISA assay.