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Planta Med 2013; 79(15): 1480-1484
DOI: 10.1055/s-0033-1350741
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

New Alkaloids from Pancratium maritimum

Sabrin R. M. Ibrahim
1   Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
,
Gamal A. Mohamed
2   Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
3   Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt
,
Lamiaa A. Shaala
4   Suez Canal University Hospital, Suez Canal University, Ismailia, Egypt
,
Diaa T. A. Youssef
2   Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
5   Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
,
Khalid A. El Sayed
6   Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA
› Author Affiliations
Further Information

Publication History

received 18 March 2013
revised 30 May 2013

accepted 10 July 2013

Publication Date:
22 August 2013 (online)

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Abstract

As a part of ongoing search efforts for the discovery of anticancer lead entities from natural sources, bulbs and flowers of the amaryllidaceous plant Pancratium maritimum have been investigated. Fractionation of the extracts of the fresh flowers and bulbs of P. maritimum led to the isolation of four new alkaloids, namely pancrimatines A (1) and B (2), norismine (3), and pancrimatine C (4), together with the previously reported N-methyl-8,9-methylenedioxy-6-phenanthridone (5), trispheridine (6), and N-methyl-8,9-methylenedioxyphenanthridine (7). The structures of these alkaloids were established on the basis of extensive 1D and 2D NMR and high-resolution mass spectral analyses as well as comparison with the literature. Compounds 2 and 7 showed antiproliferative and antimigratory activity against the highly metastatic human prostate cancer cell line PC-3 cells without cytotoxicity. The phenanthridine alkaloid class was identified as having potential for use to control prostate cancer proliferation and migration.

Key words

Amaryllidaceae - Pancratium maritimum - alkaloids - antimigratory - antiproliferative activity

Supporting Information

 

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