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Horm Metab Res 2013; 45(13): 975-979
DOI: 10.1055/s-0033-1351324
Review
© Georg Thieme Verlag KG Stuttgart · New York

Role of NUCB2/Nesfatin-1 in the Hypothalamic Control of Energy Homeostasis

A. Stengel
1   Charité Center for Internal Medicine and Dermatology, Division for General Internal and Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany
,
Y. Taché
2   Department of Medicine, CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Digestive Diseases Division UCLA, and VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
› Author Affiliations
Further Information

Publication History

received 15 May 2013

accepted 04 July 2013

Publication Date:
18 September 2013 (online)

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Abstract

Hunger and satiety are regulated in a complex fashion by a few food intake stimulatory (orexigenic) and a multitude of inhibitory (anorexigenic) factors produced in the periphery (mainly in the gastrointestinal tract) or directly in the brain. Within the brain, the hypothalamus plays a pivotal role as a production site of food intake regulatory factors. Importantly, this site integrates peripheral and central signaling factors to orchestrate food intake and in the long term body weight. Our knowledge on these regulatory pathways is not static but rather rapidly changing as new factors as well as up- and downstream signaling pathways of already known transmitters are uncovered. Hypothalamic nucleobindin2 (NUCB2), the precursor of nesfatin-1, was first described in 2006 and nesfatin-1 found to be a novel anorexigenic modulator of food intake and body weight. The initial report stimulated several groups to investigate the biological actions of nesfatin-1 and subsequent studies delineated the underlying brain mechanisms involved in its food reducing effect. Of interest was the demonstration that NUCB2 also exerts its anorexigenic action in the paraventricular nucleus of the hypothalamus and is regulated at this site by changes in metabolic status with a diurnal rhythm inversely related to that of feeding in rats. The present review describes the current state-of-knowledge on central nesfatin-1’s effects on food intake and body weight and highlights important missing links regarding cellular signaling mechanisms involved in nesfatin-1’s action.

Key words

body weight - food intake - hypothalamus - NUCB2 - nesfatin-1 - obesity - satiation
 

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