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Semin Thromb Hemost 2013; 39(07): 772-778
DOI: 10.1055/s-0033-1354425
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

FEIBA versus NovoSeven in Hemophilia Patients with Inhibitors

Massimo Franchini
1   Department of Hematology and Transfusion Medicine, C. Poma Hospital, Mantova, Italy
,
Antonio Coppola
2   Department of Clinical Medicine and Surgery, Regional Reference Center for Coagulation Disorders, Federico II University Hospital, Naples, Italy
,
Annarita Tagliaferri
3   Regional Reference Centre for Inherited Bleeding Disorders, University Hospital, Parma, Italy
,
Giuseppe Lippi
4   Clinical Chemistry Laboratory, Department of Pathology and Laboratory Medicine, University Hospital, Parma, Italy
› Author Affiliations
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Publication History

Publication Date:
08 September 2013 (online)

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Abstract

The management of patients with congenital hemophilia who develop alloantibodies that neutralize coagulation factor activity is the most important challenge for hemophilia care providers because this complication renders replacement treatment with factor concentrates partially or completely ineffective, exposing the patients to an increased risk of morbidity and mortality. Development of inhibitors complicates the clinical course of severe hemophilia in up to 30% of patients with hemophilia A and up to 5% of those with hemophilia B. Although the ultimate goal of treatment of patients with alloantibodies against factors VIII and IX is eradication of the inhibitor, the control of bleeding through high doses of factor concentrates (low titer inhibitors) or bypassing agents (high titer inhibitors) is the mainstay of management of these patients. In this review, we summarize the main characteristics of the bypassing agents FEIBA and NovoSeven, briefly discussing available literature data, and in particular, focusing on comparative studies.

Keywords

FEIBA - NovoSeven - bypassing agents - inhibitors - alloantibodies - congenital hemophilia - bleeding
 

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